Antibody Humanization and Optimization Services

Detailed sequence analysis and 3D structure modeling. Identification of the best human germline sequence templates and grafting the rodent or rabbit antibody CDR regions into the human antibodyframeworks. Identifying back- mutations and removing “hot spots” with developability issues. High-throughput lead selection and evaluation. Efficient lead preparation for research purposes in-house (up to 20mg) and CMC level protein preparation at partner facilities.