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Mtoz Biolabs Drug Development Services
23 services found
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Antibody drug developability analysis (drugability analysis) is a key strategy used to evaluate the development prospect of candidate antibody drug. This analysis is based on a comprehensive evaluation of multiple aspects of the candidate antibody, including biological activity, pharmacology, pharmacokinetics, safety, and ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Drug screening refers to the evaluated process of substances (samples) potentially used as drugs, assessing their biological activity, pharmacological effects, and therapeutic value through appropriate methods. This process encompasses biochemical and cellular levels of screening, divided into high-throughput screening (HTS) and virtual ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Many drugs target proteins that function as receptors for small-molecule ligands. These ligands bind to and alter the structures of their protein targets, thus modulating their biological activities. Key protein targets in the fields of biology and pharmaceutical research include the nuclear receptors (NRs) that belong to the superfamily of ligand-dependent transcription factors, the ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
PROTACs represent a novel strategy for protein degradation that has gained prominence recently. Utilizing bifunctional molecules, PROTACs enable the targeted ubiquitination and subsequent degradation of proteins via the UPS. PROTACs can not only offer potential therapeutic applications for a variety of conditions, including cancer, immune dysregulation, viral infections, and neurodegenerative ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
One of the main obstacles in drug development is how to deliver drugs effectively to target cells. In general, macromolecules such as proteins and mRNA cannot penetrate the cell membrane because the cell membrane has acquired protective mechanisms through evolution. ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Active Pharmaceutical Ingredients (APIs) are substances or mixtures employed in the production of drugs. They have pharmacological effects or directly contribute to diagnosing, treating, mitigating symptoms, controlling, or preventing diseases, in addition to influencing the structure or function of the body. ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
With ongoing advancements in proteomics mass spectrometry technology, there has been a notable increase in the precision of analytical instruments, resulting in a richer dataset. While this detailed protein data is invaluable for deeper scientific investigation, the vast volumes of data produced by high-throughput proteomic screenings introduce substantial challenges in analyzing protein sample ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Molecular size variation critically influences the properties of biomacromolecules such as proteins, antibodies, and peptides, especially in the realms of drug research and bioproduct manufacturing. Size Exclusion Chromatography (SEC), also known as Gel Permeation Chromatography (GPC), separates compounds based on molecular size. ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Aggregation or fragmentation of protein molecules primarily causes variations in molecular size, impacting their biological activity, stability, and their efficacy and safety as pharmaceuticals. In the development and production of biopharmaceuticals, even slight variations in molecular size can reduce drug efficacy or pose safety risks. Thus, precise detection ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
mRNA medication is a novel therapeutic method that utilizes messenger RNA (mRNA). mRNA is a sequence of ribotide that encodes for proteins and can express specific proteins through the translation process within cells. The core principle of mRNA medications is to introduce designed mRNA molecules into the patient's body to produce proteins needed for treatment by utilizing the host cell's ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Generic peptide pharmaceuticals are products that replicate existing peptide drugs. These drugs are typically composed of amino acids linked by peptide bonds and are used to treat a variety of diseases, including cancer, diabetes, and immune disorders. Developing these generics requires comprehensive research into synthesis processes, formulation ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
With the increasing focus on personalized healthcare, there is a growing demand for biomarkers for early diagnosis, prognosis, patient stratification, or monitoring treatment response. Compared with genetic biomarkers, protein biomarkers provide higher degrees of differential information. Olink proteomics is based on a unique proximity extension assay (PEA) technique that enables simultaneous ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
MtoZ Biolabs has established a comprehensive analytical platform for biopharmaceutical analysis, and is able to cover most biopharmaceutical related ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Peptides are compounds formed by multiple amino acids linked by peptide bonds and can be prepared via recombinant DNA expression, biological extraction, or chemical synthesis. Peptides represent a unique class of drugs with certain characteristics of small molecule drugs as well as properties of large proteins and other biologics. Most intrinsic signaling molecules are peptide-based, such as ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
The CUT&Tag analysis service utilizes cleavage and transposase tagging technology to precisely map the binding sites of transcription factors or histone modifications within the genome, facilitating research into DNA-protein interaction mechanisms. It provides an accurate solution for genomic and epigenetic studies. MtoZ Biolabs provides the CUT&Tag analysis service leveraging an advanced ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Proteolysis targeting chimera (PROTAC) drugs offer a novel approach to disease treatment by leveraging the body's innate protein degradation pathways. In contrast to traditional small-molecule inhibitors, PROTAC drugs promote the degradation of specific proteins rather than directly inhibiting their function, thus mitigating or eliminating their role in disease progression. ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Nanoparticles (NPs) undergo interactions with serum proteins during systemic administration, which may result in the formation of protein corona (PC). Investigating the interplay between the chemical and biological properties of NPs enhances clinical translation efficiency. NPs with PC can be considered to exhibit a distinct biological ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
With the rapid development of biotechnology, drug research and development has gradually entered a new era of precision and personalization. Targeted Protein Degradation (TPD) drugs are an emerging therapeutic strategy that utilizes the body's ubiquitin-proteasome system to degrade specific pathological proteins to achieve ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Molecular size variability is critically important in biological research and medical applications, serving not only in diagnosis and disease prevention but also in the quality control of bioproducts. Electrophoresis, particularly Sodium Dodecyl Sulfate-Polyacrylamide Gel Electrophoresis (SDS-PAGE), is revered as the gold standard for this purpose due to its high sensitivity, ease of operation, ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
In eukaryotic cells, the 3' end of mRNA is often extended with a poly(A) tail, a sequence of purine nucleotides. The poly(A) tail is a long chain of adenosine nucleotides of variable length. This tail is crucial for mRNA stability, transport, and translation. The analysis of mRNA's 3' poly(A) tail is a vital technique in studying the polyadenylation at mRNA molecules' 3’ ends, with significant ...