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Alfa Chemistry Inflammatory Mediator Services
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Binding and activation of the glucocorticoid result in the activation of lipocortin that inhibits cytosolic phospholipase A2. Lack of phospholipase A2 prevents the release of arachidonic acid, a precursor for inflammatory mediators prostaglandins and leukotrienes, thereby inhibiting inflammation. In addition, glucocorticoid also stimulates lipocortin-1 release ...