Exosomes - Extracellular Vesicles for Cancer Treatment - Medical / Health Care

Like other nanocarriers, synthetic exosomes can be used to treat different types of cancer successfully, by encapsulating the desired anti-tumoral drug or RNA and enzymes. Several studies have used engineered exosomes from dendritic or macrophage cells to release chemotherapeutic compounds as doxorubicin, paclitaxel miRNA or siRNA to induce antitumoral activity. Rodent mammary carcinoma, mice lung cancer, glioma and pancreatic cancer are just some targeted diseases in preclinical testing using exosome delivery technology. Examples of peptides and targeting ligands for exosome decoration are integrin specific RGD for mice mammary tumor or GE11 synthetic peptide for EGFR+ breast cancer.