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Molecular Sensors for Pharmaceutical Solutions - Chemical & Pharmaceuticals - Pharmaceutical
Bringing Big Pharma the Power of Continuous Quantitative Molecular Data.
Our purpose-built molecular sensor solution for pharmaceutical freeze dryers enables drug production, prevents huge product losses and optimizes the pharma manufacturing process. Lyophilisation, or the controlled removal of moisture from pharmaceutical compounds under vacuum conditions, is critical to the stability of the end product. The Atonarp LyoSentinel ensures that each process is performed exactly to plan.
A premature freeze-drying endpoint detection prior to total water removal will destabilize the whole pharma batch. Instead of relying on the traditional Pirani Pressure Gauge, the LyoSentinel is designed to detect and measure the water vapor directly, enabling more accurate secondary endpoint detection. With its enhanced sensitivity to the secondary endpoint, run-times can be optimized for significant operational savings
LyoSentinel accurate secondary drying endpoint (purple) versus Pirani Gauge (green).Wear and tear from thermal and pressure cycles can cause silicon oil leaks inside the aseptic freeze-dryer chamber that could potentially ruin an expensive batch of pharmaceuticals. The LyoSentinel proprietary filtration system detects minuscule traces of silicon oil down to 100 ppm and protects the molecular sensor hardware from degradation.
Only LyoSentinel prevents molecular sensor silicone oil degradation above but still detects is presence at ppm level.Precision vacuum leak detection
The Capacitance Diaphragm Gauge calibrated LyoSentinel monitors vacuum leaks in the freeze dryer by detecting helium. It can identify water vapor, nitrogen, oxygen, helium, and silicon oil with ± 0.3% accuracy, with a limit of detection of 500 ppm for water and 100 ppm for silicon oil. Get accurate mole fractions of each gas component with the LyoSentinel advanced proprietary algorithms.