Epitope Specific Case Study

Published example: Computationally designed epitope specific Multibody binding a cryptic epitope

• Challenge: Designing an Ab for a cryptic epitope - not exposed to solvent in the native conformation*
• N terminus covers epitope in the native conformation and desired binding site (epitope) is hidden
• Biolojic’s solution - epitope specific Antibody which moves the N terminus and binds at the desired site, leading to the desired biological effect