Apoptosis Articles & Analysis: Older
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This method is particularly valuable for identifying the target genes regulated by microRNAs (miRNAs), which are small, endogenous non-coding RNAs approximately 22 nucleotides in length. miRNAs play crucial roles in various biological processes, including cell proliferation, apoptosis, differentiation, metabolism, and responses to environmental stresses such as drought and high ...
By overexpressing particular miRNAs, researchers can study their impact on cellular functions such as proliferation, differentiation, and apoptosis. This allows for the identification of miRNA targets and the elucidation of underlying molecular pathways. ...
Ubiquitination is a post-translational modification process that involves various biological processes, including signal transduction, cell cycle regulation, cell stress responses, and cell apoptosis. It plays a crucial role in maintaining protein homeostasis, regulating various biological reactions in cells, and ensuring the normal physiological functions of organisms. ...
Cell-Based Assays Cell-based assays are employed to measure the biological activity of ADCs, including cytotoxicity, internalization, and apoptosis induction. These assays are essential for understanding the therapeutic potential of ADCs and for conducting preclinical and clinical evaluations. ...
Functional ExperimentsFor example, cell proliferation experiments, cell apoptosis experiments, etc., can directly evaluate the changes in cell function after gene knockout.Strategies to Improve the Efficiency of T Cell Gene KnockoutStrategies to improve the efficiency of T cell gene knockout can include: choosing the appropriate gene knockout tool: such as CRISPR-Cas9, TALENs, or ...
Histone acetylation is involved in cell cycle regulation, cell proliferation, and apoptosis and may play important roles in regulating many other cellular processes, including cell differentiation, DNA replication and repair, nuclear input, and neuronal inhibition. ...
MMPs promote cell proliferation, migration and differentiation, and play a role in angiogenesis, apoptosis and tissue repair. They affect endothelial cell function as well as migration, proliferation, Ca2+ signaling, and contraction of vascular smooth muscle cells. ...
Creative Bioarray provides customers with comprehensive stem cell assay development and screening service, such as: cell viability assay, proliferation, apoptosis, ion transport, pathway signaling, gene expression, protein expression, and post-translational modifications. ...
Understanding Apoptosis Apoptosis is a programmed form of cell death that eliminates damaged or unwanted cells from the body. ...
It is well known that miRNAs are involved in many essential cellular processes, such as cell proliferation, differentiation, apoptosis, stress response and tumorigenesis etc. MiRNAs function in RNA silencing and post-transcriptional regulation of gene expression. ...
The anticancer activity of alkaloids may be achieved through different mechanisms of action, such as DNA damage, inducing apoptosis, and inhibiting cell division. Tasiu Isah reviews several anticancer alkaloids from trees for drug development, including paclitaxel, camptothecin, rohitukine, harringtonine, acronycin, thalicarpine, ellipticine, usambarensine, matrines, and so on. ...
Summary When making a purchase, particularly one that can have a positive impact on your health and well-being, it’s only natural to have questions. To assist you in making informed decisions, we’ve compiled a list of 10 questions and our responses. However, we understand that each person’s needs and concerns are unique. If you find yourself with additional questions that ...
This process is essential for various cellular functions, including cell division, apoptosis (programmed cell death), and quality control of mitochondria. ...
For instance, it is widely used to diagnose abnormal cells, such as those found in cancerous tumors, by using specific molecular markers to characterize specific cellular events, such as proliferation or cell death (apoptosis). Additionally, IHC is widely used to understand the distribution and localization of biomarkers and differentially expressed proteins in different parts of ...
Tumor Necrosis Factors (TNFs): TNFs are potent proinflammatory cytokines that are involved in a variety of immune responses, including inflammation, apoptosis, and cell differentiation. Chemokines: Chemokines are specialized cytokines that direct the migration of immune cells towards sites of infection or inflammation. ...
Fucoidan derivatives have been shown to inhibit tumor cell growth, induce apoptosis, and suppress tumor metastasis. Additionally, marine polysaccharides exhibit antioxidant, anti-inflammatory, anticoagulant, and immunomodulatory activities, making them highly valuable for drug discovery and development. l Drug Delivery System In drug delivery systems, marine polysaccharides can ...
It promotes tumor cell proliferation by regulating the cell cycle, apoptosis, and signaling pathways like EGFR, β-catenin/cyclin D1, VEGF, and AKT/ERK[18]. ...
In addition to causing degradation of the target protein HER2, SignalTAC also downregulates downstream signaling (PI3K/AKT/mTOR) and promotes apoptosis and inhibits the proliferation of HER2-driven cancer cells. ...
Persistent activation of NF-κB can also lead to anti-apoptotic cell death and resistance to the apoptosis-inducing effects of chemotherapeutic agents. The above several NF-κB-mediated cancer formation mechanisms can coordinate with each other and interact at different signaling levels to jointly promote tumorigenesis and progression. ...
It inhibits the synthesis pathway of cholesterol in osteoclasts, promotes the early apoptosis of osteoclasts, and inhibits the migration and attachment of osteoclasts. ...