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Clinical Study Articles & Analysis: Older
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This ease of use has catalyzed numerous studies aimed at understanding gene function and the mechanisms underlying various diseases. Furthermore, it has led to accelerated timelines for preclinical and clinical trials, ultimately benefiting patients awaiting lifesaving therapies. ...
Brain tumors represent a significant oncology challenge due to their complex genetic profiles and diverse clinical manifestations. To date, scientists have leveraged various therapeutic avenues, including precision medicine, targeted therapies, and immunotherapy. ...
However, not all the individuals that snore have sleep apnea, as per the clinical study published in Journal of Clinical Sleep Medicine. It showed that nearly 60% of people that have primary snoring do not suffer with sleep apnea. ...
The prime concern resides in assessing the clinical efficacy of these therapies, as their long-term impact is yet to be conclusively quantified. Hence, an extensive lattice of regulations envelops these modalities, mandating rigorous preclinical studies and clinical trials before their eventual public deployment. ...
GMP growth factors and cytokines designed for therapeutic manufacturing are an essential component of defined media. To date, the cell therapy industry has accepted GMP terms for this reagent class, despite the fact that there is no direct oversight by regulators. These proteins are intended for use in further manufacturing processes and do not come into direct contact with patients. In fact, ...
Discover how matched tumor-normal sequencing can help clinical researchers detect the somatic origin of variants with certainty. In the era of precision oncology, it has become increasingly common for patients diagnosed with cancer to undergo tumor sequencing. Identifying the mutations that make up a tumor’s genomic landscape can help guide selection of targeted therapies and inform ...
Medical advancement relies on clinical trials, which are essential for the development of safe and effective innovative treatments. However, the success and general applicability of these treatments heavily depend on the diversity of the participants involved¹?³. This blog explores the importance of achieving data diversity in clinical trials to enhance clinical trial results and ...
Sialic acid proteins are a special type of glycoproteins, characterized by the presence of sialic acid at the end of the sugar chain. Sialic acid is a biologically important sugar molecule that plays a crucial role in many intercellular interactions, including cell recognition, adhesion and signal transduction. Therefore, the detection of sialic acid proteins holds significant value in disease ...
Here are some specific examples to illustrate the selection of the number of parallel samples in different situations.Basic Biological ResearchIn basic epigenomics research, such as studying how the methylation status of a gene affects gene expression, at least three parallel samples are usually needed. This can help researchers distinguish between biological variation and ...
Elastase in Pathological Conditions One of the most well-studied conditions involving elastase is emphysema, a form of chronic obstructive pulmonary disease (COPD). ...
In response to the emerging needs in global healthcare, SOPHiA GENETICS has just revealed the New Generation SOPHiA DDM™ Platform, aiming to stay at the forefront of precision medicine and address today the healthcare needs of tomorrow. ...
This technique can evaluate the binding affinity, specificity, and cellular uptake of ADCs, providing essential data for preclinical and clinical studies. Surface Plasmon Resonance (SPR) SPR is a label-free technique used to study the binding interactions between the antibody and its target antigen. ...
ESMO updated its recommendations for NGS in advanced cancers this year, urging broader use of NGS in additional cancer types and the inclusion of tumor-agnostic biomarkers. The ESMO Precision Medicine Working Group (PMWG) first published its recommendations for when to use next-generation sequencing (NGS) in routine practice for patients with metastatic cancers in 20201. At that time, based ...
CD Formulation strives to match the batch size of key clinical study samples with commercial production batches. This alignment ensures that the manufacturing process is mature and scalable. ...
With professional knowledge of PC (particularly intra-tumor heterogeneity, TME crosstalk, and micro-environmental instability) and powerful cross-platform collaboration capability, Alfa Cytology has launched a series of PC vaccine development services to meet pre-clinical research needs. The PC vaccine development services at Alfa Cytology are more targeted & feasible and ...
Drug DevelopmentPlays an important role in the discovery and verification of drug targets, and the study of drug action mechanisms.DIA proteomics sequencing technology has become an important tool in proteomics research due to its high-throughput, high-sensitivity, and comprehensiveness. With the continuous progress of analysis software and data processing capabilities, DIA ...
Understanding Sleep Apnea and Its Types Sleep apnea is a sleep-related breathing disorder that results in poor sleep quality and can lead to daytime fatigue or sleepiness, forgetfulness, and irritability. According to the Mayo Clinic, there are 3 types of sleep apnea to be aware of as follows: OSA or obstructive sleep apnea is the more common form of the disorder and affects roughly 30% of ...
In order to be truly effective, a CDM system must be able to handle large amounts of data, be user-friendly and utilise artificial intelligence to automate tedious manual tasks. Mid Study Changes Clinical Data Management is a complex process. It involves multiple stakeholders, from investigators to sponsors and CROs. This can make CDM challenging, especially when ...
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Pre-clinical studies also help investigators determine the optimal capsule, route of administration, and indirect side effects of the drug. It is only through repeated and varied pre-clinical studies that researchers can ensure that cases retain confidence in the therapy when entering the clinic. In a word, the ...
In a significant stride towards eradicating a debilitating disease, a new polio vaccine has achieved WHO prequalification. This development represents a crucial milestone in global health, where effective vaccination remains our strongest defence. With a novel design intended to tackle a persistent challenge of the virus, this vaccine is poised to bolster our fight against the spread of ...