Device Based Therapy Articles & Analysis: Older
20 articles found
"Anti-drug antibodies" (ADA) typically refer to antibodies produced by the immune system against certain drugs, especially biologics. When patients receive certain biological treatments (such as monoclonal antibody therapy), their immune system may produce these antibodies, which may affect the safety and effectiveness of the drugs. ADA testing is done to determine whether these anti-drug ...
Pulmonary fibrosis, particularly idiopathic pulmonary fibrosis (IPF), represents a significant challenge in healthcare due to its detrimental impact on lung function and limited treatment options. While WNT/β-catenin signaling plays a crucial role in lung development and maintenance of adult lung stem cells, its dysregulation has been associated with pulmonary fibrosis. However, recent ...
The lifetime of devices is typically based on several factors, such as: Expected wear and tear The likelihood of material degradation or corrosion The potential for changes in performance over time Additionally, the shelf life of a medical device can be affected by a range of environmental factors, including: Temperature Humidity ...
In the search for innovative and effective ways to target cancer, we are faced with more than just a challenging problem; we are faced with our own cells as opponents. Cancer cells evolve to achieve an optimum of physical fitness, giving them an array of abilities that no cell should possess in a healthy organism. One way to find novel therapies against cancer therefore could imply finding a ...
Antibody-drug conjugate (ADC) is one of the fastest growing fields in tumor therapy, which consists of monoclonal antibody (Antibody), linker (Linker) and active drug (Payload). So far, there are only 15 drugs on the market in the world. However, with the development of some perfect antibody modification techniques, advanced site-specific coupling techniques and powerful small-molecule toxins, ...
Chitin is the second largest natural polymer after cellulose, and it exists widely in nature, such as shells of crustaceans such as shrimps, crabs, insects, and cell walls of fungi. Although chitin has good biocompatibility and biodegradability, its poor solubility limits its practicality in the field of biomedicine. The product of chitin deacetylation is chitosan. Chitosan is structurally ...
Abstract: A concern regarding osteochondral autograft transfer for chondral defects is donor-site morbidity of the knee, the most common source of the autograft. To avoid the drawbacks of osteochondral autograft transfer, a cylindrical osteoperiosteal graft harvested from the iliac crest covered by a same-sized cylinder of hyaluronic acidebased polymer scaffold pretreated with bone marrow ...
Challenges Faced in Studies of Device-Based Therapies for ADHF While the details of future studies will depend highly on device particulars, there are several common key strategic, clinical, regulatory, and reimbursement questions applicable to the devices reviewed in this paper. ...
Alucent Biomedical Inc. is rethinking peripheral artery disease (PAD) treatment with a novel natural scaffolding technology based on a light-activated drug therapy delivered via a balloon catheter. This first-of-its-kind drug-device therapy, known as Natural Vascular Scaffolding (AlucentNVS), is designed to provide a more natural ...
Alzheimer's disease (AD) is a progressive, irreversible neurodegenerative disease clinically manifested by cognitive impairment, behavioral abnormalities, and social deficits. It is predicted that by 2050, the number of people 65 and older with dementia in the United States could reach 13.8 million. In China, more than 15.07 million elderly people aged 60 or over suffer from dementia, of which ...
The pelvic floor physical therapy system is a therapeutic method that uses physical therapy concepts to recondition the pelvic floor muscles in a systematic, effective, and safe manner. The treatment’s purpose is to increase the strength and function of the pelvic floor muscles, as well as to relieve discomfort, weakness, and inefficiency. A qualified physical therapist accesses the muscles ...
Amsterdam, the Netherlands – Royal Philips (NYSE: PHG; AEX: PHIA), a global leader in health technology, today announced that it has signed an agreement to acquire Vesper Medical Inc., a US-based medical technology company that develops minimally-invasive peripheral vascular devices. ...
What are AAVs? and what makes them good candidates for gene therapy? In two previous posts, we introduced gene therapy, a method for curing genetic diseases by providing healthy copies of defective genes, and Adeno-associated virus (AAV) capsids, the gene therapy delivery system Dyno focuses on. In those posts, we also discussed how natural variants of AAV did not evolve for the specialized ...
The US Food and Drug Administration (FDA) requires that all medical devices are identified with a unique device identifier (UDI), in both human and machine-readable forms. ...
At the beginning of Chinese New Year, Beijing Yaguo Technology Co., Ltd.'s innovative medical device "Respiratory Power" respiratory neuromuscular stimulator was officially launched. "Respiratory power" has been established in 2015 as a core innovative product of Yaguo, Through 4 years of continuously efforts, after research, demonstration, design, development, and clinical registration it has ...
The primary safety endpoint of the study is device- related or procedure-related major adverse events through 30 days. ...
Interim study results from systolic heart failure patients treated with percutaneous therapy designed to improve left ventricular function presented at TCT 2019 Santa Clara, Calif.–September 25, 2019–Ancora Heart, Inc., a company developing a novel therapy to address heart failure, today announced results from an interim analysis of heart failure patients treated in the CorCinch FMR ...
New results support the feasibility of an entirely extracardiac pacing method in a heterogeneous patient population, using a minimally invasive, parasternal delivery approach, with adequate sensing and thresholds suited for temporary pacing. The study, authored by Anne-Floor BE Quast, Niek EG Beurskens (University of Amsterdam, The Netherlands) and colleagues, was recently published in ...
Abstract Introduction The ZAP-X is a novel self-contained and first-of-its-kind self-shielded therapeutic radiationdevice dedicated to brain and head and neck radiosurgery. By utilizing a 2.7-MV linearaccelerator and incorporating a design in which a beam stop and major mechanical elementsserve a radiation shielding function, the Zap-X does not typically require a radiation bunker.The unique ...
Quantum Dots (QDs) are nano–particles carrying high stability fluorescence to follow the grafted cells which can be used in investigating the movement of cells and understanding the organogenesis of stem cells during development and wound repair processes in adulthood. For its easy acquirement and bypassing moral ethical issues, it makes the human adipose derived stem cells an attractive, ...