Drug Release Articles & Analysis: Older
57 articles found
Role of Liposomes in Drug Delivery The structure of liposomes, consisting of an aqueous core enclosed by a lipid bilayer, allows for the encapsulation of both hydrophilic and lipophilic drugs. ...
Antibody-drug conjugates (ADCs) are a new class of drugs that combine the advantages of both antibodies and small molecule toxins. ...
They are widely used in the pharmaceutical and biotechnology industries for drug delivery, controlled release systems, and other applications due to their unique properties and versatility. ...
There are many different molecules in ADCs, and the difference between these molecules lies in the drug-to-antibody ratio (DAR) value and/or the site where the antibody binds to the drug. In addition, ADCs prepared by the current production process usually contain non-ADC forms, including naked antibodies and free small molecule drugs. When the ...
Dendrimers have attracted much attention in drug delivery, imaging, and materials science due to their unique structure, high monodispersity, and tunable properties. ...
Furthermore, nanoformulation can provide controlled and sustained release of drugs, maintaining therapeutic levels in the system for extended periods, reducing the frequency of dosing and improving patient compliance. ...
The field of pharmaceuticals has seen rapid advancements in drug delivery technologies in recent years, one of which is long-lasting controlled-release microspheres technology. ...
For example, through carboxylic acid functional groups, PEGs can covalently bind to drugs, targeting ligands, or other biologically active molecules, thus enabling drug-targeted delivery and controlled release. ...
In SN38-BSA bioconjugate, a type of bioconjugate called a protein-drug conjugate is created. Here, the drug (SN38) is directly linked to BSA. ...
It has been approved by the U.S. Food and Drug Administration It is certified by the Food and Drug Administration (FDA) and is a copolymer material available on the market. PLGA has good biocompatibility, biodegradability, mechanical strength, good plasticity, surface modification, and drug encapsulation. It has a wide range of uses in the field ...
Ordinary nanogels will swell when absorbing water, and their drug administration and subsequent release behavior will be single. Environmentally responsive nanogels will swell or dissolve when exposed to different environments, and their administration and subsequent release behavior will be more intelligent. ...
In order to more effectively deliver chemotherapy drugs, Small Molecule Drug Conjugates (SMDC), Antibody Drug Conjugates (ADC), and Degradation Antibody Conjugates (DAC) have been successively explored and developed, enhancing the therapeutic index while providing selective delivery. ...
Recombinant human collagen, a natural biosynthetic material with good biocompatibility, low immunogenicity, degradability and absorbability, has been widely used in hemostasis, wound healing, drug slow-release carrier and tissue process. And it can be processed by electrospinning technology. ...
Transdermal drug delivery system is a type of drug formulation that is absorbed into the body circulation through capillaries at a certain rate through the skin to produce drug effects. Transdermal drug delivery systems allow the drug to continuously diffuse through the skin, penetrate and absorb into the blood ...
Polymer nanoparticles can also be engineered to release drugs in a controlled manner, increasing their efficacy and reducing potential side effects. ...
The selection of hyaluronic acid, which improves the swelling capacity of the prescription and increases the speed of drug release and transdermal absorption efficiency. The use of hydrophobic mold material to prepare microneedles maintains the integrity of the needle shape and the uniformity of drug loading. Full analytical testing of ...
Liposomes: Liposomes can be used to deliver a variety of drugs, whether they are hydrophobic or hydrophilic, as the drugs can be embedded in the bilayer of the liposomes or inside the liposomes. ...
The linker is not only the molecule part of the covalent link between the antibody and the small molecule payload, but also a key element with design properties in targeted drug therapy. The addition of the linker should not induce aggregation and needs to ensure acceptable PK characteristics, while limiting the premature release of the payload in plasma and ...
However, the drug release is slow when it deviates from the phase transition temperature. ...
This directs the liposomes and their cargo right to where they're needed, reducing side effects and improving therapeutic efficacy. Controlled release: Liposomes can be engineered to release their drug payload slowly and steadily over time, maximizing the therapeutic effect and minimizing the need for frequent dosing. ...