Epitopes Articles & Analysis: This-Year
7 articles found
The carboxylated version is ideal for binding studies and functional assays, whereas non-carboxylated MGP may be used for antibody generation, epitope mapping, or as a control in mechanistic investigations. Recombinant MGP is typically purified using affinity chromatography and validated by SDS-PAGE, Western blot, and mass spectrometry to confirm integrity and modification ...
The proteins used in VLP formation are often derived from the virus itself, ensuring that the resulting particles present the same epitopes that can trigger an immune response. This feature is particularly advantageous in vaccine development, where the aim is to elicit an immune reaction without exposing individuals to pathogenic viruses. ...
Reduced Immunogenicity PEG masks antigenic epitopes on therapeutic proteins, minimizing antibody-mediated neutralization. ...
ADCs with PEG linkers show slower plasma clearance and longer half-life. l Reduced Immunogenicity: By preventing protein aggregation and shielding payload epitopes, PEG linkers lower the risk of immune recognition. PEG-encapsulated ADCs often exhibit reduced antibody responses and toxicity. l Enhanced Targeting: More soluble and stable ADCs better reach tumor cells. ...
Meanwhile, aberrant O-glycosylation in mucins creates the CA125 epitope used to monitor ovarian cancer progression. Glycan-directed therapies are emerging rapidly. ...
The rapid processing of frozen samples preserves the native state of proteins and cellular components, making it particularly suitable for analyses that require the recognition of specific epitopes. Furthermore, the quick preparation allows for timely assessment of experimental outcomes, which is crucial in dynamic research environments. ...
Their unique structure allows them to access challenging targets that conventional antibodies cannot, including hidden epitopes and conformational structures on proteins. Advantages of Single-Domain Antibodies Size and Specificity: Their small size enables them to penetrate tissues more effectively and reach targets that larger antibodies cannot. ...