Fibrosis Lung Articles & Analysis
6 articles found
Precision-Cut Lung Slices (PCLS) have emerged as a innovative ex vivo model that allows researchers to explore deep into lung physiology, disease mechanisms, and pharmacological responses. By offering a unique combination of biological complexity and controlled experimental conditions, PCLS serve as a critical bridge between the limitations of traditional in vitro cell cultures and the ...
Pulmonary fibrosis, particularly idiopathic pulmonary fibrosis (IPF), represents a significant challenge in healthcare due to its detrimental impact on lung function and limited treatment options. While WNT/β-catenin signaling plays a crucial role in lung development and maintenance of adult lung stem cells, ...
For example, one study found that only 34.5% of Americans living in rural areas had access to a pulmonologist within 10 miles of their home, compared with 97.5% of those living in more urban areas.2 A similar study described the same lack of access to imaging services, finding that 77.8% of patients eligible for lung cancer screening had to drive more than 30 minutes to find a ...
As an example, breathing is a key functional endpoint in patients with lung fibrosis. As the severity of fibrosis increases, elastic and functional tissue in the lungs is replaced with inelastic scar tissue, which makes breathing a challenge. ...
I presented part of my doctoral research on how macrophages play a regulatory role in lung injury and fibrosis. During the meeting, I had several conversations with Dr. ...
Idiopathic pulmonary fibrosis (IPF) is a chronic and fatal lung disease. A maladaptive epithelium due to chronic injury is a prominent feature and contributor to pathogenic cellular communication in IPF. Recent data highlight the concept of a “reprogrammed” lung epithelium as critical in the development of lung ...