Inflammation Chronic Articles & Analysis
14 articles found
However, the same proteolytic activity that protects against pathogens can, when unregulated, contribute to tissue injury, autoimmune inflammation, and chronic disease progression. In recent years, recombinant ELANE protein has become an indispensable tool for researchers studying neutrophil function, protease regulation, and disease mechanisms, particularly in ...
Weight and sleep interconnected and that fact is oftentimes overlooked. If you are having issues sleeping or wake up frequently at night, did you gain weight recently? If you have, you are not alone. Many studies have shown that weight gain does lead to poor sleep and can impact REM sleep, due to hormonal imbalances and sleep disorders, such as sleep ...
The balance of inflammatory and anti-inflammatory signals produced by SMECs is crucial, as dysregulation can lead to chronic inflammation, often associated with conditions such as muscular dystrophy and other muscle-wasting diseases. Beyond their roles in blood flow regulation and inflammation, SMECs contribute to metabolic functions within ...
In sepsis, a life-threatening condition characterized by systemic inflammation in response to infection, TREM1 expression is markedly upregulated, contributing to the overwhelming cytokine release and tissue damage observed in septic patients. ...
Abstract Background: Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by chronic inflammation of synovial joints. Anticitrullinated protein autoantibodies are detected by the CCP test in early disease and predict the development of erosive disease as well as extraarticular manifestations. ...
Relationship Between Immunity, Inflammation and Cancer Immunity is an act of self-protection of the body. ...
Activation of MAPK leads to transcription of inflammation genes regulated by AP-1 (activator protein-1), while phosphorylation of Ikβ α (a negative regulator of NF-κB) by Ikβ kinase leads to the translocation of NF-κB to the nucleus, aiding in the transcription of key inflammation genes, thus generating numerous inflammatory mediators ...
This type of infection triggers an acute phase of inflammation that can lead to scar tissue and reduced contractile function in the chronic phase that all lead to HFrEF. [4] For HFpEF patients, it’s the low-grade chronic systemic inflammation that plays a key role in microvascular changes. This type of ...
In addition, drug activity was also observed in paclitaxel-resistant cells. 3. Targeted Treatment of Inflammation The nuclear transcription factor kappaB (NF-κB) is a vital transcriptional regulator in cells. ...
The most frightening cases involved advanced, chronic gum disease which showed a 4 times higher increase in neck and head cancer for every millimeter of bone loss around teeth. ...
Hyperglycemia in conjunction with dyslipidemia induces insulin resistance and provokes release of proinflammatory cytokines resulting in chronic inflammation, accelerated lipid peroxidation with further development of atherosclerotic alterations and diabetes. ...
Tumor Necrosis Factor Alpha (TNF-a) is a potent cytokine that is over-expressed by cells during chronic intestinal inflammation. Furthermore, TNF-a represents the most validated clinical target for ulcerative colitis (UC) and inflammatory bowel diseases (IBD) with multiple emerging neutralizing/inflammation-reducing therapeutics targeting this ...
In the early stages, periodontal disease causes redness and swelling (inflammation) of the gums. In advanced stages, that is, periodontitis, the underlying bone is damaged, resulting in tooth loss. ...
ByMatexcel
Affecting about 8.4% of children in the United States, pediatric asthma is a chronic inflammation in the airways that results in difficulty breathing. Although the severity of the inflammation can vary, the results and symptoms are generally the same. ...
ByAluna