Metabolic Activators Articles & Analysis: Older
30 articles found
Anorexia, a condition characterized by a significant reduction in food intake despite negative energy balance, poses severe risks to health and quality of life. It manifests in various forms in humans, including anorexia nervosa and physiological anorexia. While psychological and social factors have been widely studied, the physiological causes remain less understood. For ground squirrels, ...
Bacteria, however, can also provide some benefits, such as: · Production of micronutrients · Aiding metabolism or activation of medicines · Biotransformation of bile salts · Fermentation of indigestible polysaccharides · Prevention of luminal colonisation by pathogenic microorganisms What ...
Circular Dichroism (CD) uses the absorption properties of optically active substances to analyze the molecular structure of drugs. It has very valuable applications in drug analysis, including:1. Identification of Drug StereochemistryMany drug molecules are chiral, and their activity, metabolism, and toxicity can significantly differ due to ...
Common viability assays include the MTT assay, which measures mitochondrial activity, and the ATP assay, which quantifies ATP levels, an indicator of metabolic activity. ...
Metabolism is the assembly of biochemical reactions in living organisms, the material basis for life maintenance of living organisms, and an important basis for the study of life activities. Metabolomics studies the endogenous metabolic activities of life under the influence of the internal and external environments, including ...
AMPK (Adenosine 5'-monophosphate (AMP)-activated protein kinase), as an important kinase regulating energy homeostasis, is one of the central regulators of eukaryotic cell and organism metabolism. ...
Previously, it was thought that glial cells, which support neuronal activity, metabolize most of the glucose in the brain. However, by using induced pluripotent stem cells, the researchers found that neurons were able to take up glucose and process it into smaller metabolites. ...
It can not only identify the microbial of microbial species present but also provide insight into the functional roles and metabolic activities of the microorganisms. The coupling of this method with function-based activity is a powerful technique for the discovery of new functional genes from uncultured microbes. ...
They are important for their ability to regulate important processes in bacteria, such as iron metabolism, virulence and quorum sensing, and to adapt quickly to changing environments. ...
It can not only identify the microbial species present but also provide insight into the functional roles and metabolic activities of the microorganisms. The coupling of this method with function-based activity is a powerful technique for the discovery of new functional genes in uncultured microbes. ...
The company's scientists perform whole-genome sequencing (WGS) to understand the activity level of every gene in a specific disease model, which allows new discoveries to be made. ...
Due to the widespread distribution of CYP450 and its important role in metabolism in vivo, more than 90% of clinical DDI is caused by the alteration of CYP450 activity. Predicting metabolic models in the early stage of drug discovery is of great significance to improve the success rate of drug discovery. ...
All of these modifications do not change the genome sequence, but they do change the way the cell uses the same set of genetic codes, thus altering phenotypes and metabolic activities. The epigenome is also inheritable. Epigenetic modifications provide a stable mechanism by which cells with the same genotype can regulate their gene expression and exhibit ...
Bidirectional Effects Through years of research, it has been revealed that intestinal flora can synthesize a range of enzymes involved in drug metabolism, including oxidases and hydrogenases. These enzymes can activate, deactivate or reactivate drugs through structural changes in their composition. ...
The findings were published in Cell Stem Cell, entitled "PPARdelta activation induces metabolic and contractile maturation of human pluripotent cell-derived cardiomyocytes". These authors investigated multiple metabolic modifications of hPSC-CMs. They also determined the role of a metabolic switch from glycolysis to fatty acid ...
Furthermore, glucose metabolism in the liver was increased during early morning activity, indicating that hepatic glycogen is a preferentially utilized raw material during early morning exercise. ...
In addition, the blue and UV wavelengths have been shown to enhance the plant defense mechanism by initiating metabolic activity responsible for terpene and cannabinoid synthesis. ...
The current study focuses on further developments of a new class of antagonists and their role in the regulation of lipoprotein metabolism. A structural activity relationship (SAR) study of over 250 analogues was conducted around our hit molecules and tested for their ability to inhibit the PCSK9/LDLR interactions. ...
Methods The surface roughness and contact angle of PEEK and ANAB PEEK was measured. Cell metabolic activity, proliferation and alkaline phosphatase (ALP) was measured and cell attachment was determined by quantifying adhesion plaques with cells. Results ANAB treatment increased the surface hydrophilicity [91.74 ± 4.80° (PEEK) vs. ...
At this elevated concentration, metabolic activity is increased, reducing surplus nutrients in the aquatic environment. ...