Metabolic Gene Articles & Analysis
8 articles found
Comparative genomic analyses reveal that commercially available L. acidophilus powders differ markedly in key functional elements: Bacteriocin production genomics: Strains such as L. acidophilus NCFM contain complete operons for lactacin B production, while others (e.g., La-14) exhibit truncated bacteriocin genes, resulting in differential antimicrobial capacities. Carbohydrate ...
This phenotype is mainly due to the upregulation of lipogenesis-related genes at multiple levels of transcriptional, translational and post-translational modifications, and enzymatic activity, as well as the impact on oncogene expression due to changes in these genes or lipid metabolism. ...
This question is answered in a recent publication published in Cell Metabolism. Researchers discovered, using a mouse model, that exercise at different times of the day has varied impacts on local and systemic metabolism. ...
Transcriptional profiling using cDNA microarrays and follow-on quantitative real-time PCR analysis revealed a relative derepression of aerobic metabolism genes in carbon monoxide (CO)-induced anoxia when compared to nitrogen (N2) gas-induced anoxia, which is consistent with the known oxygen-mimetic effects of CO. ...
The diversity and distribution of a bacterial community from Coffee Pots Hot Spring, a thermal spring in Yellowstone National Park with a temperature range of 39.3 to 74.1°C and pH range of 5.75 to 6.91, were investigated by sequencing cloned PCR products and quantitative PCR (qPCR) of 16S rRNA and metabolic genes. The spring was inhabited by three Aquificae ...
Using DNA microarray and quantitative reverse transcription-PCR (RT-PCR) analyses, we found that sigB disruption led to reduced transcript levels of genes involved in the metabolism of glucose into organic acids. This in turn resulted in retardation of glucose consumption by cells under conditions of oxygen deprivation. These results indicate that SigB is ...
We present here a novel Aspergillus nuclear protein, LaeA, as a global regulator of secondary metabolism in this genus. Deletion of laeA (laeA) blocks the expression of metabolic gene clusters, including the sterigmatocystin (carcinogen), penicillin (antibiotic), and lovastatin (antihypercholesterolemic agent) gene clusters. ...
We present here a novel Aspergillus nuclear protein, LaeA, as a global regulator of secondary metabolism in this genus. Deletion of laeA (laeA) blocks the expression of metabolic gene clusters, including the sterigmatocystin (carcinogen), penicillin (antibiotic), and lovastatin (antihypercholesterolemic agent) gene clusters. ...