On Innovative Organ On A Chip Articles & Analysis
4 articles found
By using PDX, drug developers can screen multiple drug candidates simultaneously, optimizing therapeutic strategies based on the unique biological features of each tumor. Another innovative approach is the development of organ-on-a-chip technology. This method involves creating micro-engineered environments that mimic the architecture and ...
This phase assesses the pharmacodynamics (how the drug affects an organism) and pharmacokinetics (how the organism affects the drug). Through this testing, researchers determine optimal dosages, routes of administration, and potential side effects. ...
Recent advancements in technology, including the development of organ-on-a-chip systems and genetically modified animal strains, are paving the way for more sophisticated and relevant preclinical models. These innovations enhance the ability to study the liver in the context of the whole organism while providing detailed insights ...
Due to a lack of robust in vivo gut models, animal studies are generally required to evaluate gut toxicity. However, these studies can be lengthy and expensive and may not accurately recapitulate the behavior of the human gastrointestinal tract. Drugs are thus often developed with undesired gut side effects that are not apparent until clinical trials. Organ-on-a-chip models are the closest ...