Preclinical Trial Articles & Analysis: This-Year
15 articles found
ELANE, or neutrophil elastase (NE), is a serine protease stored in the azurophilic granules of neutrophils and is encoded by the ELANE gene on chromosome 19. It plays a pivotal role in the host defense system by degrading bacterial proteins, remodeling extracellular matrices, and shaping inflammatory responses. However, the same proteolytic activity that protects against pathogens can, when ...
Matrix Gla Protein (MGP) is a small, vitamin K-dependent extracellular matrix protein that plays a critical role in the regulation of vascular calcification and bone development. As a natural inhibitor of pathological mineralization, MGP has attracted significant attention in cardiovascular and skeletal biology research. The development of recombinant MGP protein has enabled researchers to study ...
Tissue cross-reactivity studies play an essential role in the understanding of immune responses, particularly in the context of autoimmunity, transplant rejection, and vaccine development. These studies aim to identify whether antibodies or T cells generated against a particular antigen react with similar proteins found in different tissues, which can lead to unintended effects and complications. ...
Lipids, often simply thought of as fats, play a far more complex and vital role in our bodies than just energy storage. They are fundamental building blocks for cell membranes, crucial for nutrient absorption, and, significantly, the precursors to a powerful class of signaling molecules: steroid hormones. Understanding the deep connection between Lipid Metabolism and these hormones, along with ...
According to active collaboration with scientists and clinical experts, the company promotes innovation and speeds up laboratory discoveries to help preclinical practice. Through strategic partnerships, Alfa Cytology focuses on developing FAP-targeted therapies that provide advanced tools for researchers to revolutionize cancer treatment protocols. ...
Ischaemic heart diseases continue to be a major global health concern and a leading cause of death. To develop more effective treatments, it is essential for researchers to work with animal models that closely replicate human cardiac physiology. In a notable step forward, Pius et al. present a refined, minimally invasive ovine model of ischaemia–reperfusion–infarction which ...
The company seeks to advance innovation and improve the preclinical implementation of laboratory breakthroughs through its collaboration with scientists and oncologists. ...
In Vitro and In Vivo Studies: Prior to human trials, extensive laboratory studies are conducted to evaluate the efficacy, stability, and safety of the conjugate. ...
Alfa Cytology unveils advanced PD-1 inhibitor development service for cancer research. Alfa Cytology, a prominent service provider in the oncology landscape, has recently launched its innovative PD-1 inhibitor development services. This initiative marks a significant advancement in the quest for more effective cancer therapies, focusing on enhancing precision and adaptability in treatment ...
The quest for effective therapeutics begins long before a drug reaches clinical trials. One of the cornerstones of this process is drug screening in animal models, which plays a pivotal role in evaluating the safety and efficacy of potential treatments. ...
Preclinical drug discovery represents a critical phase in the development of new therapeutics. ...
Services provided include comprehensive support in drug development, preclinical trial design, and strategic planning for laboratory discoveries into preclinical ...
Moreover, the services on ovarian cancer model development allow researchers to utilize state-of-the-art preclinical models that closely mimic human ovarian cancer biology. These models enable the in-depth study of tumor behavior and therapeutic response, facilitating the discovery of novel treatment avenues tailored to individual patient profiles. ...
Leukemia, a malignant disorder of the blood and bone marrow, poses significant challenges to both patients and healthcare providers. Traditional treatments, including chemotherapy and radiation, while effective for some, often come with severe side effects and varied success rates. Enter immunotherapy - a groundbreaking approach that is not only redefining leukemia treatment but also offering ...
The evaluation of cardiovascular toxicity is a significant challenge in drug development. Preclinical evaluation of cardiovascular safety involves a multifaceted approach, encompassing a plethora of in vitro and in vivo endpoints. These assessments continuously evolve, aiming to mitigate the incidence of cardiovascular toxicity that may emerge during clinical ...