Tumor Immunity Articles & Analysis: Older
22 articles found
Dr. Kate Sasser from Tempus led a discussion on the potential of antibody-drug conjugates (ADCs), their challenges in targeting tumor antigens, and the future of cancer treatment with Dr. Daniel Johnson, Dr. Funda Meric-Bernstam, and Dr. Kellogg Parsons. The oncology field is rapidly advancing with the development of antibody-drug conjugates (ADCs), offering new hope for ...
ByTempus
To ensure the effectiveness and safety of these antibody drugs, it is necessary to perform activity testing.Definition of Antibody ActivityThe activity of an antibody drug usually refers to its ability to bind to the target antigen and how it affects the target in a biological function, such as neutralizing viruses, killing tumor cells, or regulating immune ...
Cancer is a complex disease that involves a delicate interplay between the tumor cells and the host immune system. Cytokines play a critical role in this interplay, mediating the communication between different cells of the immune system and modulating immune responses. ...
Cancer is a complex disease that involves a delicate interplay between the tumor cells and the host immune system. Cytokines play a critical role in this interplay, mediating the communication between different cells of the immune system and modulating immune responses. ...
NIR-PIT drugs can form a new targeted anti-tumor platform that irradiates infrared light to the tumor site through the device. ...
Cytokines, including interleukins, tumor necrosis factor, interferons, chemokines, colony-stimulating factors, growth factors, etc., are involved in the activation, proliferation, differentiation and survival of various immune cells. ...
CADM and Cancers CADM1 and Tumor Immune Escape In the process of tumor development, cancer cells can adopt various strategies to evade detection and destruction by the immune system, allowing them to grow and spread unchecked. CADM molecules, particularly CADM1, have been implicated in tumor ...
It is involved in the formation and development of the tumor microenvironment (TME) and plays an important role in regulating immune responses. ...
Applications of Click Chemistry 1. Sugar-mediated tumor immunity Bertozzi, who has long been interested in sugars coated on the surface of cells, used "click chemistry" to create antibody-enzyme conjugates that reshape sugar calyces, as well as Lysosome-targeting chimera (LYTAC) that degrade membrane-bound and extracellular targets. For example, human ...
High internalization is not necessarily beneficial to the treatment of solid tumors, because the rapid degradation of ADCs limits their ability to penetrate tumor masses. ...
Summary Inflammation is a hallmark of the tumor microenvironment and an area of active investigation. To better understand how tumor inflammation differs from general inflammation, such as in gum disease, Drs. ...
Some circRNAs can interact with microRNAs, regulate translation processes and participate in the terms of immune responses. Some circular RNAs can interact with RBPs and act as "protein sponges". ...
Background Recent studies of NSCLC have highlighted genetic abnormalities that underlie these tumors. These genetic abnormalities generate abnormal proteins that have not been previously seen by the patient’s immune system which, in turn, activates antitumor immune responses that control tumor initiation and progression. ...
The combination of an IL-6 blocker with an immune checkpoint inhibitor reduced experimental autoimmune encephalomyelitis (EAE) symptoms and improved tumor control, suggesting that the combination suppresses inflammatory responses and may enhance antitumor immunity. ...
Aberrant glycosylation is a common hallmark of many malignancies and is important at all stages of tumor growth. Glycosylation regulates a range of physiopathological processes, including cell-cell adhesion, cell-matrix interactions, epithelial-mesenchymal transition, tumor proliferation, invasion, metastasis, and angiogenesis. Different mechanisms of aberrant ...
One reason for this is that pancreatic cancer is a "cold tumor" that the immune system is unable to recognize and eliminate. ...
Background Tumor immunotherapies compose immune checkpoint inhibitors, therapeutic antibodies, tumor vaccines, cellular therapies, and so on. ...
The advent of immune checkpoint inhibitors (ICI) has improved the overall survival of patients with a variety of malignancies. ...
The ultimate goal of cancer vaccines is to fully activate the immune system so that it can recognize tumor antigens and eradicate tumor cells, and nanotechnology possesses the qualities required to do this. Nanovaccine technology, as one of the candidates for cancer immunotherapy with configurable components and sequential integration, will most ...
Why do we need new cell contenders in the CAR field? Well, different CAR immune cells have different advantages and sometimes unique challenges or limitations. ...