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Many oncology drugs have been abandoned by pharmaceutical companies due to poor performance in phase I, II, or III clinical trials. These drugs represent untapped potential treatments for indications outside of those initially investigated. With research and development costs for a single new drug estimated between $2–3 billion, abandoned drugs represent an opportunity to bring drugs to ...
Summary When it comes to surgical precision, most surgeons know the value of excellent loupes and proper ergonomics, but lighting often gets overlooked. And yet, the right lighting setup can make a noticeable difference in clarity, comfort, and even surgical outcomes. Here are two simple but powerful lighting tips that are easy to implement and surprisingly ...
In surgical tissue recovery, focus is on controlling infection, managing inflammation, and ensuring wound closure. Beneath the surface—anatomically and biologically— the extracellular matrix (ECM) is undergoing remodeling ensure long-term tissue integrity. The ECM is a dynamic, biologically active network that orchestrates the entire process of tissue repair, remodeling, and ...
The home healthcare market is experiencing rapid growth as patients seek more convenient, comfortable care outside of hospitals. Whether managing chronic conditions, receiving post-operative care, or utilizing wearable medical devices, patients and providers alike demand medical components that are safe, reliable, and effective in non-clinical settings. Fluoropolymer tubing—PTFE, PFA, and ...
When you're just starting out in the world of healthcare, whether as a nursing student, medical trainee, or phlebotomy learner, few things feel as nerve-racking as your first needle insertion. You've read the textbooks, watched the tutorials, and maybe even practiced on an orange or a banana, but when it comes to human skin, confidence often lags behind theory. This guide is for you - the ...
In the intricate world of cellular biology, proteins are the undisputed workhorses. They are assembled based on a genetic blueprint, but their story doesn't end there. After synthesis, proteins undergo a vast array of chemical modifications known as post-translational modifications (PTMs). These changes act as molecular switches, fine-tuning a protein's function, localization, and stability. ...
ELANE, or neutrophil elastase (NE), is a serine protease stored in the azurophilic granules of neutrophils and is encoded by the ELANE gene on chromosome 19. It plays a pivotal role in the host defense system by degrading bacterial proteins, remodeling extracellular matrices, and shaping inflammatory responses. However, the same proteolytic activity that protects against pathogens can, when ...
Matrix Gla Protein (MGP) is a small, vitamin K-dependent extracellular matrix protein that plays a critical role in the regulation of vascular calcification and bone development. As a natural inhibitor of pathological mineralization, MGP has attracted significant attention in cardiovascular and skeletal biology research. The development of recombinant MGP protein has enabled researchers to study ...
When you hear the word "sterol," your mind probably jumps to one famous, and often misunderstood, molecule: cholesterol. We’re constantly bombarded with messages about "good" and "bad" cholesterol, and its impact on our cardiovascular health. But what if I told you that cholesterol is just one member of a vast and vital family of molecules called sterol lipids? This diverse group is ...
In the bustling city of the cell, proteins are the tireless workers. They build structures, carry messages, and catalyze the chemical reactions essential for life. But a protein's job isn't static. Its function, location, and even its lifespan are tightly controlled by a series of modifications. Among the most versatile and critical of these is Protein Ubiquitination, a process that acts like a ...
Medical technology has seen remarkable advancements over the years, and radiopaque marker bands are among the innovations that have revolutionized the precision and safety of procedures involving medical devices. As a critical component in many medical instruments, these small yet highly effective devices ensure that surgeons and healthcare professionals perform accurately in high-stakes ...
Population growth, aging populations and increases in cancer incidence have necessitated new approaches to identifying effective treatments. One such approach involves the repositioning, or repurposing, of drugs already FDA approved in either non-oncology disease states and/or approved in a limited number of tumor types. The repurposing of these drugs for new indications represents an ...
A paper on the detection of phospholipids from skin via DMS has been published! The IonVision system was tested with porcine skin, and then further refined to analyze a small number of human basal cell carcinoma and healthy skin samples. The classification accuracies achieved (over 90 %!) encourage us to plan studies with a larger number of skin samples. The research article is available as ...
Virus-like particles (VLPs) have garnered significant attention in recent years for their potential applications in vaccine development, drug delivery, and as tools in various biotechnological fields. These nanoparticles mimic the structure of viruses but lack the viral genetic material that makes viruses infectious. This unique characteristic offers a versatile platform for various innovative ...
Human ovarian epithelial cells play a crucial role in ovarian function and have become a significant focus in cancer research, specifically ovarian cancer. The ability to study these cells in a laboratory setting has been greatly enhanced through the development of immortalized human ovarian epithelial cell lines, particularly those that utilize the SV40 (Simian Virus 40) large T antigen. ...
Immortalized human podocytes represent a significant advancement in the field of renal research, offering scientists an unprecedented opportunity to study kidney function and pathology. These specialized cells play a crucial role in the filtration barrier of the kidneys, and their immortality allows for extended experimentation beyond the limitations of primary cell cultures. Podocytes are unique ...
Induced pluripotent stem cells (iPSCs) have revolutionized the field of regenerative medicine and cellular biology. They are derived from somatic cells that have been genetically reprogrammed back into an embryonic-like pluripotent state. This transformation enables them to differentiate into any cell type, offering significant potential for disease modeling, drug discovery, and therapeutic ...
Abstract In pharmaceutical synthesis, heavy metal catalysts are commonly used, and their residues often remain in the final product. These heavy metals—primarily from catalyst residues—not only affect drug efficacy but also pose serious health risks to patients. As a result, pharmacopoeias in various countries impose strict limits on heavy metal content in pharmaceutical substances. ...
A recent study led by Decan Jiang and colleagues from RWTH Aachen and Heidelberg University Hospitals in Germany has shed light on how porcine models are helping surgical training—particularly in the complex field of kidney transplantation. Pigs are anatomically and physiologically close to humans, making them ideal candidates for surgical training. Practicing renal ...
Advancements in medical technology have transformed healthcare, with radiopaque marker bands playing a crucial role in modern medical devices. These small components enhance precision and visibility during medical procedures and have become a key part of catheter designs, improving accuracy and efficiency. Edgetech Industries, a leading radiopaque marker bands manufacturer, provides high-quality ...