Variation of bone forming ability with the physicochemical properties of calcium phosphate bone substitutes

Six commercially available CaP bone substitutes (Bio-Oss, Actifuse, Bi-Ostetic, MBCP, Vitoss and chronOs) as well as two tricalcium phosphate (TCP) ceramics with either a micron-scale (TCP-B) or submicronscale (TCP-S) surface structure are characterized and their bone forming potential is evaluated in a canine ectopic implantation model.

It has been demonstrated that the specific topography and more specifically the microporosity appears to be the necessary trigger for osteoinduction. Among the six commercial available calcium phosphate bone substitutes, only MBCP™ can be considered as an osteoinductive scaffold thanks to a unique know-how.