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AtlasXomics Inc. articles
Highlights
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Deterministic barcoding in tissue enables NGS-based spatial multi-omics mapping
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DBiT-seq identified spatial patterning of major tissue types in mouse embryos
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Revealed retinal pigmented epithelium and microvascular endothelium at cellular level
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Direct integration with scRNA-seq data allows for rapid cell type identification
Highlights
- Simultaneous transcriptomic and proteomic analysis on fixed tissue slides
- 10- and 25-μm spot size for varying resolution and near-single-cell analysis
- DBiT-seq can be conducted with common laboratory equipment and reagents
- DBiT-seq produces high-quality RNA sequencing data with high spatial resolution (10 μm)
This protocol describes the use of the determini
Microfluidic channels provide a means to deliver barcodes encoding spatial information to a tissue, which allows co-profiling of gene expression and proteins of interest in a spatially resolved manner.
Back in 2013, Rong Fan from Yale University was intrigued by a conversation with colleague Kathryn Miller-Jensen: they noticed that trypsinizing cancer cells off the substrate could perturb the measurements of the signaling network. Since then, Fan has been thinking about how to fix
Our fifth annual round-up of the tools that look set to shake up science this year.
From gene editing to protein-structure determination to quantum computing, here are seven technologies that are likely to have an impact on science in the year ahead.
Fully finished genomes
Roughly one-tenth of the human genome remained uncharted when genomics researchers Karen Miga at the University of California, Santa Cruz, and Adam Phillippy at the National