Bio-Technical Resources, a Division of Arkion Life Sciences, LLC services

BTR microbiologists and molecular biologists have worked with a large spectrum of microorganisms. We have successfully applied two general approaches to strain development: Classic mutagenesis, screening and selection. Advanced recombinant methodologies.

BTR has the experience to provide strain or process development services that meet your needs. Should you need both services, combining classical and/or recombinant strain improvement with a solid fermentation development program is the fastest, most cost effective way to develop an economical commercial process. BTR has proven this approach with a record of over 55 years of commercial R&D success producing biomass, antibiotics, chemicals, enzymes/proteins, and a variety of other products.

Protein production using recombinant technologies continues to revolutionize all aspects of life and life sciences. Essentially, a gene encoding a protein of interest is expressed to make the protein at dramatically enhanced yield and or with greatly improved characteristics in the native organism or in heterologous hosts. Recombinant production of proteins involves transforming cells with a desired gene in a DNA vector. The gene then translates into its corresponding protein. The expressed protein can then be extracted by lysing the cells and subsequent purification steps. In some cases, the protein made in the cells is exported into the culture medium through protein secretion machineries.