CD BioGlyco. articles
Carbohydrates, the ubiquitous energy source for life, are intricate molecules that play a fundamental role in various biological processes. Their synthesis is a testament to nature's ingenuity.
Carbohydrate synthesis, a subfield of organic chemistry, delves into the intricate methods of constructing these essential molecules. It encompasses a wide spectrum of techniques, from the simple formation of monosaccharides, the building blocks of carbohydrates, to the elaborate a
Sugar nucleotides are key molecules in the biosynthesis of glycans, which are carbohydrate chains found on the surface of cells or in the bloodstream. These molecules play a critical role in a wide range of biological processes, including cell signaling, protein folding, and immune responses. In this article, we will delve into the structure and synthesis of sugar nucleotides, and explore their importance in glycobiology.
The Structure of Sugar Nucleotides
When we feel uncomfortable, we tend to eat less, drink less, and exercise less. This is not unique to humans—most animals reduce these three behaviors when fighting infection.
Recently, a new study pinpoints clusters of neurons that control these responses (uncomfortable behavior). By provoking immune responses in mice, the researchers demonstrated that specific cell populations in the brainstem could effectively induce three suggestive uncomfortable behaviors. In a
Glycosaminoglycan (GAG) is a general term for the glycan part of proteoglycan macromolecules. Glycosaminoglycans are large linear polysaccharides composed of repeating disaccharide units, and their main configuration contains amino sugars and uronic acids (glucuronic acid and/or iduronic acid). Glycosaminoglycans can be divided into chondroitin sulfate, dermatan sulfate, keratan sulfate, hyaluronic acid, heparin and heparan sulfate categories.
Glycoprotein prostaglandin D2 synthase (PTGDS) is a member of the lipocalcitonin superfamily that plays a dual role in prostaglandin metabolism and lipid transport. PTGDS is involved in various cellular processes including solid tumorigenesis, but its role in tumorigenesis is paradoxical, and the significance of PTGDS in hematologic malignancies is not clear. The aim of this new study was to investigate the expression and function of PTGDS in diffuse large b-cell lymphoma (DLBCL), especially