Creative Bioarray articles
Introduction
hERG, which stands shorthand for the human Ether-à-go-go-Related Gene, generates the protein responsible for a certain type of potassium channel in the human heart, denoted as IKr or Kv11.1. The role of this potassium channel is fundamental for normal cardiac function, playing a vital role in the termination of the cardiac action potential and ultimately contributing to the heart's rhythmicit
Hepatocytes are the chief functional cells of the liver, responsible for the selective uptake, metabolism and excretion of most drugs. Cells for use in plate cultures or suspension assays represent a key tool for predicting properties such as hepatotoxicity, metabolism, and potential drug-drug interactions. Since these cells mimic the properties of the liver, researchers can evaluate the metabolism, drug-drug interaction and toxicity of drug candidates in a cost-effective manner.
Because neural stem cells (NSCs) have the potential of self-renewal and multidirectional differentiation, the method of suspended neural bulb culture can be used to obtain and study. After processing the embryonic brain tissue into a single cell, only the cells with the ability of self-renewal can be cloned and proliferated into a suspended nerve ball in the culture medium, and w
Antibodies can often be used in multiple assays, but they do not perform equally well in all assays. This is particularly true for immunohistochemistry (IHC). IHC has now become an indispensable assay and is consistently performed in anatomic pathology to give specific diagnosis and subclassification of neoplasms.
IHC is a complex assay, where the end result is influenced by a variety of parameters in the pre-analytic, the analytic, and the post-analytic phase. In order to provide a ro
The clinical presentation of COVID-19-related illness ranges from asymptomatic to mild respiratory symptoms resembling influenza infection to acute symptoms including pneumonia requiring hospitalization and admission to the intensive care unit. COVID-19 starts in the upper airways and lungs, but in severe cases can also affect the heart, blood vessels, brain, liver, kidneys, and intestines. Understanding the functional characteristics and cellular tropism of SARS-CoV-2, as well as the pathoge