Refined Laser Systems GmbH applications

The PICUS DUO by Refined Laser Systems is a cutting-edge laser source engineered for coherent Raman scattering (CRS) imaging, specifically optimized for both coherent anti-Stokes Raman scattering (CARS) and stimulated Raman scattering (SRS). CRS is a label-free imaging technique that leverages the interaction of two synchronized laser beams of different colors to probe molecular vibrations within a sample. This approach allows for the detailed visualization of various chemical components without the need for dyes, making it particularly valuable in biomedical and clinical settings. The PICUS DUO is built on low-noise fiber technology, providing sensitive multicolor SRS imaging with shot-noise limited relative intensity noise (RIN) at -157 dBc/Hz across its tuning range. This system enables rapid live and hyperspectral imaging, capable of tuning the excitation wavelengths in merely 5 ms, facilitating the application of CRS in environments where time is critical, such as surgical procedures or extensive research studies.