RoosterBio, Inc. products

RoosterCollect™-EV-CC is a standardized chemically defined, and low particulate collection medium for scalable and streamlined extracellular vesicle (EV) collection. RoosterCollect-EV-CC is one component of RoosterBio’s CliniControl™ EV Production System – a bioprocess engine for rapid EV manufacturing for use in cGMP and clinical applications.  Each bag of RoosterCollect-EV-CC is engineered to support and integrate with RoosterBio’s batch (2D) and fed-batch (3D) CliniControl™ hMSCs and bioprocess media to support a rapid path to phase 1 and scaling to grow with your clinical progression.

RoosterCollect-EV Pro™ is a translation-friendly, low particulate, chemically defined Extracellular Vesicle (EV) collection media kit designed to increase total hMSC-EV yields.  For use post-cell expansion, this medium supports cell health during hMSC-based EV collection to elongate the collection window, increase EV yields, and reduce variability in 3D Bioreactor as well as 2D flask culture systems.

The RoosterKit-hBM-1M-XF contains 500 mL of RoosterNourish-MSC-XF and 1 vial of 1M cryopreserved hBM-MSCs (RoosterVial-hBM-1M-XF, Part No. MSC-031). RoosterNourish-MSC-XF is our translation-friendly, highly-productive, xeno-free (XF) bioprocess medium for the rapid expansion of human mesenchymal stem/stromal cells (hMSC) from multiple tissue sources.  RoosterVial-hBM-1M-XF (Part No. MSC-031) contains 1M cryopreserved hBM-MSC identical to our 10M cell product, RoosterVial-hBM-10M-XF (Cat. No. MSC-030). Following the provided RoosterBio protocols this affordable kit can generate >100M cells within 10 days. Lots are released based on hMSC identity (cell surface marker expression), expansion, viability, sterility, and differentiation and provided QC Brief containing industry-leading functional characterization (immunomodulatory potential (IDO assay), angiogenic cytokine secretion).

RoosterVial™-hBM are Human Bone-Marrow Derived Mesenchymal Stem/Stromal Cells (hBM-MSCs) isolated from adult human iliac crest from a variety of normal, healthy donors and expanded to a population doubling level (PDL) of 6-10, post-mononuclear cell isolation.  Available in both 1M or high-volume 10M cell per vial formats to meet your needs throughout product development. Each lot is release tested to expand >10-fold within 4 to 6 days in a media exchange free process when paired with RoosterNourish-MSC bioprocess medium and conforms to ISCT minimal criteria for hMSC identity including cell surface marker expression and tri-lineage differentiation potential, expansion potential, and sterility. Accompanying QC brief contains industry-leading functional characterization including immunomodulatory potential (IDO assay) and angiogenic cytokine secretion, giving added confidence in quality, reproducibility, and ease of integration.

RoosterVial™-hBM-XF are Human Bone-Marrow Derived Mesenchymal Stem/Stromal Cells (hBM-MSCs) isolated from adult human iliac crest from a variety of normal, healthy donors and expanded to a population doubling level (PDL) of 6-10, post-mononuclear cell isolation.  Available in both 1M or high-volume 10M cell per vial formats to meet your needs throughout product development.

RoosterVial™-hUC-XF are Human Umbilical Cord Derived Mesenchymal Stem/Stromal Cells (hUC-MSCs) isolated from the perivascular Wharton’s Jelly region of the human umbilical cord and expanded to a population doubling level (PDL) of 6-10, post-mononuclear cell isolation.  Available in both 1M or high-volume 10M cell per vial formats to meet your needs throughout product development.

cGMP xeno-free human bone marrow-derived MSCs to support allogenic therapeutic cell manufacturing. Using a comprehensive and qualified supply chain of our high volume, well-characterized, and standardized WCBs (working cell banks) for large scale cell manufacturing – you’re now able to bypass major steps in cGMP manufacturing. With a rapid 2D process and path to Phase 1 – using 20 x 10-layer vessels, CliniControl™ hMSCs and media get you to the clinic faster, and then scale with your clinical progression to meet your lot size requirements.

Engineered from the ground up, RoosterGEM was built to radically increase transduction efficiency as part of a simplified, efficient, and economical hMSC-genetic engineering platform. Traditionally, genetic modification of primary cells has low efficiency of transfer requiring increased MOI and viral agent costs, with significant time and resources allocated to media and process optimization.  RoosterGEM is a highly efficient Complete Genetic Engineering Medium, formulated to increase transduction efficiency and reduce viral agent MOI and associated costs in one simplified, off-the-shelf medium.

RoosterNourish™-MSC is a translation-friendly, bioprocess medium designed to eliminate media exchanges during rapid expansion of human mesenchymal stem/stromal cells (hMSCs) from multiple tissue sources. This medium supports in vitro expansion of hMSCs in a 2D batch process.  RoosterNourish™-MSC has unparalleled productivity (Millions of cells produced per Liters of media consumed) compared to other MSC media on the market. Used alongside our RoosterVial™-MSC and following RoosterBio® protocols, we guarantee 10X hMSC expansion within 4-6 days.