SCIREQ - an emka TECHNOLOGIES Company articles
In a preclinical study published in Scientific Reports, Hill et al. evaluated whether sub-normothermic storage at 10°C with continuous, low-volume ventilation could extend donor-lung viability in a murine model.
Study design
Over a 24-hour preservation period, three methods were compared: static storage at 4°C, static storage at 10°C, and 10°C storage with continuous, low-volume ventilation.
Key findings
- Reduced lung injury: decreased
Idiopathic pulmonary fibrosis (IPF) remains a challenging respiratory disease characterized by progressive lung scarring, with current therapies only slowing disease progression. A 2026 study of human and animal models identifies concurrent inhibition of the transcription regulators ID1 and ID3 as a potential therapeutic approach, given their upregulation in fibroblasts from diseased tissue.
Dual targeting of ID1 and ID3
- Single-agent inhibition is insufficien
While the dangers of primary smoking are well-known, nearly half of the U.S. population remains at risk from the silent threat of secondhand smoke (SHS). Chronic exposure to SHS triggers a cascade of inflammation and vascular damage that can lead to irreversible conditions like COPD and emphysema.
A recent study from Sturgis et al. (2025) has demonstrated a p
In the world of preclinical lung cancer research, seeing a tumor is only half the battle. While traditional imaging like microCT can show us where a mass is located, it often fails to tell the full story: How is that tumor actually affecting the animal’s ability to breathe?
A recent pilot study by
Abstract
Cannabis is used by an estimated 192 million people around the world. Most people use cannabis through the inhalation of cannabis smoke, which contains combustion by-products that can negatively affect lung health. Knowledge of these risks has led to a growing interest in cannabis vaporizers, which heat the dry cannabis flower without burning. Vaporizing cannabis still releases cannabinoids for inhalation but heats the plant material at a lower temperature. T
Emily T. Wilson;Ilan B. Urovitch;Percival Graham;Rui Liu;Cory S. Harris;David H. Eidelman;Carolyn J. Baglole
Idiopathic pulmonary fibrosis (IPF) is a devasting lung disease characterized by progressive scarring of lung tissue. As fibrosis develops, patients experience worsening shortness of breath, reduced lung capacity and ultimately respiratory failure. Current therapies for IPF rely on oral administration of pirfenidone and nintedanib, two FDA-approved drugs that slow disease progression. While effective, oral dosing requires high systematic concentrations, which often lead to gastrointestinal si
In preclinical respiratory studies, traditional methods like plethysmography often require animal restraint and extensive acclimation, limiting their ability to capture dynamic respiratory changes.
To overcome these challenges, IPS Therapeutique Inc. validated a novel telemetry-based technique for continuous monitoring of intrapleural pressure and respiratory patterns in conscious, freel
Obesity is a significant contributor to respiratory disorders such as Obesity Hypoventilation Syndrome (OHS) and sleep apnea, both of which are characterized by reduced respiratory chemosensitivity. These conditions not only impair breathing but also exacerbate the health risks associated with obesity. Recent research from
Precision-Cut Lung Slices (PCLS) have emerged as a innovative ex vivo model that allows researchers to explore deep into lung physiology, disease mechanisms, and pharmacological responses. By offering a unique combination of biological complexity and controlled experimental conditions, PCLS serve as a critical bridge between the limitations of traditional in vitro
Despite international treaties, the use of chemical weapons remains a concern nowadays. Organophosphorus-nerve agents (OPs) act by inhibiting cholinesterases (ChE), preventing the degradation of some neurotransmitters. Their excessive accumulation can impair neuronal transmission, leading to cholinergic syndrome, which can cause symptoms such as respiratory failure and, in severe cases, death.
Oximes are molecules that can reverse the effect of OPs. While they can be used as treatment