Synergy Biomedical, LLC products

BioSphere Putty is based on an innovative form of 45S5 bioactive glass.  The Putty utilizes Synergy`s unique spherical bioactive glass particles with a optimized, bimodal size range. The combination of the BioSphere particles and a resorbable, phospholipid carrier results in a bioactive Putty with the highest bioactive glass content on the market, excellent handling, and improved bone healing..

The BioSphere® MIS Putty graft delivery system is precision engineered to extrude BioSphere® Putty through a cannula designed for minimally invasive surgery (MIS).

The BioSphere MIS II Putty graft delivery system is precision engineered to extrude BioSphere® Putty through a cannula designed for minimally invasive surgery (MIS).

BioSphere Flex is a bone graft that was specifically developed to maximize the bone healing potential of bioactive glass.  Using Synergy’s proprietary BioSphere Technology, BioSphere Flex is composed of innovative bioactive glass granules combined with a porous collagen/sodium hyaluronate carrier.

BioSphere Flex Sp Extremities is a bone graft that was specifically developed to maximize the bone healing potential of bioactive glass.  Using Synergy’s proprietary BioSphere® Technology, BioSphere® Flex SP Extremities is composed of innovative bioactive glass granules combined with a porous collagen/sodium hyaluronate carrier.

BioSphere Flex SP is a bone graft that was specifically developed to maximize the bone healing potential of bioactive glass.  Using Synergy’s proprietary BioSphere® Technology, BioSphere® Flex SP is composed of innovative bioactive glass granules combined with a porous collagen/sodium hyaluronate carrier.

Data Driven Performance - In Vivo Study Results; Bioactive glass has typically been used in a particulate form consisting of irregular particles and a broad size range (32-710 um).  Instead of creating a bone graft with these "off-the-shelf" particles, Synergy utilized a unique spherical particle shape and conducted an in vivo optimization study to determine the size range that provided the best bone healing. Testing in a rabbit bone defect model showed that the Putty composed of 10:90 mix of 90-180 um spheres and 355-500 um spheres provided the best healing.

• The 45S5 formulation of bioactive glass has been the primary material used in today`s bioactive glass bone graft products (45% SiO2, 24.5% CaO, 24.5% Na2O, and 6% P2O5).