Fentanyl (FYL) Detection Kit - Manual

Fentanyl is a synthetic opioid related to the phenylpiperidines. Fentanyl is approximately 100 times more potent than morphine. This agent is highly lipid soluble and rapidly cross the blood-brain barrier. This is reflected in the half-life for equilibration between the plasma and cerebrospinal fluid of approximately 5 minutes for fentanyl. The levels in plasma and cerebrospinal fluid decline rapidly owing to redistribution of fentanyl from highly perfused tissue groups to other tissues, such as muscle and fat. As saturation of less well-perfused tissue occurs, the duration of effect of fentanyl and sufentanil approaches the length of their elimination half-lives of between 3 and 4 hours. Fentanyl undergoes hepatic metabolism and renal excretion. Therefore, with the use of higher doses or prolonged infusions, fentanyl becomes longer acting.