Model E(z) - Histone-Lysine N-Methyltransferase Datasheet

Histone-lysine N-methyltransferase (Ez) is a Polycomb group (PcG) protein, and a catalytic subunit of the Esc/E(z) complex. By methylating Lys-9 and Lys-27 of histone H3, this complex is involved in transcriptional repression of target genes. E(z) is important for the repression during the first six hours of embryogenesis. The Esc/E(z) complex, together with the recruitment of the PRC1 complex, is necessary for the repression of homeotic target genes. Alternative names: Lysine N-methyltransferase 6, Protein enhancer of zeste.