PROPEL - Instructions For Use - Brohcure

The PROPEL sinus implant contains mometasone furoate (active ingredient), a synthetic corticosteroid with anti-inflammatory activity. Mometasone furoate is a white to off-white powder. The chemical name is 9?,21-dichloro-11?,17?-dihydroxy-16?-methylpregna-1,4- diene-3,20-dione 17-(2-furoate), with the empirical formula C27H30Cl2O6, and a molecular weight of 521.43 g/mol. Mometasone furoate is a hydrophobic drug that is practically insoluble in water. Mometasone furoate is stable under aqueous, acidic and oxidative conditions. MF can degrade under extreme basic, thermal and photolytic conditions. The chemical structure is shown below. The drug is embedded in a bioabsorbable polymer matrix containing poly-(DL-lactide-co-glycolide) and polyethylene glycol (inactive ingredients) which provides for gradual release of the drug.