Reaction Biology - Model ASH1L- [BRD] - Bromodomain Proteins - Brochure

Human recombinant ASH1L bromodomain. ASH1L is a large (333 kDa), multi-domain protein associated with actively transcribed regions of chromatin. Its bromodomain lies C-terminal to its SET domain, which confers histone H3K36 methyltransferase activity. ASH1L is the human homolog of Drosophila Ash1, a Trithorax group protein. Like its counterpart in Drosophila, ASH1L has been found to play a role in the regulation of Hox gene expression. The ASH1L bromodomain displays strong binding to various Lys(Ac) residues in singly acetylated histone peptide microarrays (histones H1.4K74Ac, H2AK36Ac, H2BK85Ac, H3K56Ac, H4K59Ac/K79Ac).