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Beyond Cancer Publishes Pre-Clinical Data in Cancer Cell International Demonstrating Its Tumor Ablation Method Utilizing Ultra-High Concentration Nitric Oxide (UNO) Induced a Systemic Response that Prevents Metastases

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Dec. 12, 2022
Courtesy ofBeyond Air Inc

Beyond Cancer, Ltd., an affiliate of Beyond Air, Inc. (NASDAQ: XAIR) that is focused on developing ultra-high concentration nitric oxide (UNO) for the treatment of solid tumors, announced today the publication of pre-clinical data demonstrating that its proprietary tumor ablation technology utilizing UNO results in a potent innate and adaptive immune response that prevents metastases and resulted in a statistically significant survival benefit.

The data were published in an article entitled, “Gaseous Nitric Oxide Tumor Ablation Induces an Anti-Tumor Abscopal Effect,” in the peer-reviewed journal Cancer Cell International (“CCI”). The article is available at (click here).

“Beyond Cancer’s novel implementation of ultra-high concentrations of nitric oxide to treat solid tumors has repeatedly resulted in data demonstrating an immunostimulatory response,” stated Dr. Hila Confino, Chief Scientific Officer. “By locally ablating tumors with UNO we have shown that the recruitment of antigen-presenting cells (APCs) triggers T-cells to proliferate and mature, producing a long-term systemic immune response that reduces distant metastases and prolongs survival in mice.”

Dr. Frederick Dirbas, MD, Associate Professor of Surgery, Div of Surgical Oncology, Dept of Surgery, Stanford University School of Medicine commented, “Beyond Cancer’s UNO technology data in the published manuscript demonstrates promising immunotherapeutic responses with the possibility of being a novel treatment for solid tumors.”

The manuscript published in CCI describes several studies of in-vitro and in-situ tumor ablation utilizing a single intratumoral treatment of UNO with secondary anti-tumor effects. In one study, CT26 tumor-bearing mice were treated with a single 5-minute administration of 50,000 ppm gaseous nitric oxide (gNO) or 20,000 ppm gNO versus naïve control. Two weeks post gas treatment, the tumors were resected and a week later a secondary tumor was induced in the contralateral flank. As shown in the figure below at day 55, all of the mice treated with 50,000 ppm gNO rejected the secondary CT26 cell inoculation versus none of the mice in the naïve group. In addition, 73% of the mice treated with 20,000 ppm gNO rejected the secondary inoculation, also a significantly better result than naïve control. By Day 75, the conclusion of the study, 89% of the mice treated with 50,000 ppm gNO and 64% of the mice treated with 20,000 ppm gNO rejected a secondary inoculation, compared to none of the mice in the naïve group.

The Kaplan-Meier analysis in the figure above shows statistical significance for survival in UNO treated CT26 tumor-bearing mice versus control. There was also a separation between the 50,000 ppm arm and the 20,000 ppm arm implying a potential dose response.

“These impressive data published in the peer-reviewed journal CCI support our understanding of UNO as an immunomodulating therapeutic option for the treatment of solid tumors,” said Dr. Selena Chaisson, Chief Executive Officer. “Throughout the year, the team at Beyond Cancer has made incredible progress translating the entire preclinical effort for UNO into the clinic via the first-in-human Phase 1 trial. We look forward to further elucidating the powerful effects of UNO on human tumors.”

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