Galapagos to present encouraging initial data from FILOSOPHY real-world arthritis study at ACR Convergence 2022

Galapagos NV (Euronext & NASDAQ: GLPG) will present new data on filgotinib at the American College of Rheumatology (ACR) Convergence 2022 meeting taking place in Philadelphia, Pennsylvania from 10-14 November 2022.

Dr. Walid Abi-Saab, Chief Medical officer, at Galapagos said, “We are excited to present data at ACR which highlights our continued commitment to patients and the healthcare provider community, in particular initial data from our first international, real-world arthritis study. We believe that it’s not only important to control disease activity to prevent long term irreparable disability, but also to take a comprehensive approach to the disease by aiming at improving quality of life of patients and their families. These initial results are encouraging, and we look forward to seeing further results as the study continues.”

Over the last two decades, disease activity in rheumatoid arthritis (RA) has improved, yet fatigue and pain continue to hinder patients’ quality of life (QOL), and ability to function.^2,3 Less than 30% of patients are satisfied with their pain levels and 40-80% of RA patients are affected by fatigue.^4,5 Pain and fatigue have negative impacts on mental and physical QOL, including social functioning.⁶

Interim data from the FILOSOPHY study of patients aged ≥18 years with moderately to severely active RA, who are prescribed filgotinib for the first time, showed rapid improvements in pain (VAS scale) and fatigue as early as week 1, with mean changes from baseline in VAS pain score of -11.9 and -22.2 at Week 1 and Month 1, respectively, and from baseline in FACIT-F⁷ score of 3.7 and 6.8 at Week 1 and Month 1, respectively.¹ The FILOSOPHY study also showed improvements in disease activity, with a mean change from baseline in Clinical Disease Activity Index (CDAI) score of -13.7 at Month 1.¹ The interim results are based on data from 200 patients enrolled in Germany, the United Kingdom, the Netherlands, Belgium, and Italy, representing real-world patients with moderately to severely active RA.¹

Other abstracts being presented at ACR Convergence 2022 include analyses of filgotinib safety, and clinical outcomes, in adult patients with RA with up to 8.2 years of exposure to filgotinib, including the most recent integrated safety data from 7 clinical trials (pooled phase 2 and 3 clinical data) that looked at the overall RA population as well as at subgroups of patients with risk factors for cardiovascular events, and another abstract describing laboratory results from a long-term Phase 3 extension study. Two encore abstracts will be presented on the effect of filgotinib on body weight and BMI, and insights from a post-hoc analysis of filgotinib integrated safety data.