Glyco-engineered Mammalian Cell Expression System Released at CD BioGlyco

CD BioGlyco, a biotechnology company that provides a full range of glycobiology-related products, analysis, custom synthesis, and design to help advance glycobiology research, recently released a glyco-engineered mammalian cell expression system to help scientists with their research.

New biotherapeutic glycoproteins, such as recombinant monoclonal antibodies (mAbs), have been widely used to treat many diseases. Numerous studies have shown that appropriate glycosylation can improve protein properties, such as increased stability, prolonged half-life, and decreased immunogenicity. It has been demonstrated that N-glycans attached to the constant region of an antibody are critical to the biological efficacy of the antibody, and minor modifications in the N-glycan structure can also determine the potency of IgG effector functions, such as complement-dependent cytotoxicity (CDC) and antibody-dependent cell-mediated cytotoxicity (ADCC).

Currently, the number of therapeutic glycoproteins produced on mammalian expression platforms is increasing. This trend is caused by an increased awareness of the importance of post-translational modifications (PTMs). The development of genetic modification strategies for mammalian cells not only improves specific production rates, but also optimizes their glycoform distribution to increase their therapeutic activity.

With years of experience in glycoengineering, CD BioGlyco now provides the following Glyco-engineered mammalian cell expression systems:

Human cell line

Chinese hamster ovary cells (CHO)

Baby hamster kidney cells (BHK)

According to the basic information on bioglyco.com, the system can be utilized for biopharmaceutical research, improving the biological activity of recombinant protein, genetic engineering drug production, discovery of new genes and glycoprotein structure and function research.

The company provides a variety of mammalian cell lines for glycoprotein production. The optimized expression vector and expression strategy can greatly improve the expression yield under the premise of ensuring product stability. If you feel interested and want to know more, please visit https://www.bioglyco.com/glyco-engineered-mammalian-cell-expression-system.html or send email to contact@bioglyco.com.