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In Vitro Model Articles & Analysis: Older
16 news found
IVS’s functional 3D tissue models reconstitute the physiological properties of human cardiac, smooth and skeletal muscle as well as connective tissues that support cancer growth. ...
According to the classification of drugs and the characteristics of pharmacological effects, the efficacy and mechanism of drugs are reflected through appropriate in vitro and in vivo models, providing a basis for new drug development and supporting clinical research. ...
ArterioSorb has been shown to show decreased acute thrombus formation compared to thicker strut bioresorbable scaffolds (BRS) in an in-vitro model. Shengjie Lu PhD, of the National Heart Research Institute and National Heart Centre Singapore, presented a moderated poster at TCT 2017 in Denver, showing the impact of BRS strut thickness on the formation of ...
MatTek Life Sciences will distribute Cell4Pharma’s ciPTEC renal cells and utilize the technology in the development of a new in vitro kidney model. MatTek Life Sciences, a Boston-area tissue engineering company and a member of the BICO Group, announced today it has entered into a distribution agreement and strategic partnership with Cell4Pharma, a ...
"As previously announced, we already have seen early success, suggesting the ability of ImmCelz® to achieve superior results in a pre-clinical, in-vitro model system that should be amenable to safe, scalable and rapid clinical translation." ...
” The effect of STARs treatment on lysosomal function was presented from studies in two different models – the GD-iPSC-derived dopaminergic neurons, and a BE(2)-M17 dopaminergic-like neuron model expressing mutant GBA. The presentation titled “Development of Structurally Targeted Allosteric Regulators for the Treatment of Neuronopathic Gaucher ...
The collaboration leverages Prellis’ EXIS platform that can break tolerance mechanisms in vitro to create high affinity human antibodies targeting human proteins. ...
Prellis Biologics announced today that it has closed a $14.5 million Series B financing round, led by Celesta Capital and current investor Khosla Ventures Prellis will use the proceeds to advance its Externalized Immune System (EXIS™) platform, a first-in-class in vitro, fully human antibody discovery, and vaccine screening workflow. “The EXIS platform offers ...
Prellis Biologics announced today that it has closed a $14.5 million Series B financing round, led by Celesta Capital and current investor Khosla Ventures Prellis will use the proceeds to advance its Externalized Immune System (EXIS™) platform, a first-in-class in vitro, fully human antibody discovery, and vaccine screening workflow. “The EXIS platform offers ...
Through control of properties such as substrate mechanical stiffness and adhesion ligand presentation, materials can be designed that enable more physiologically relevant extracellular environments and better direct cellular behaviors within 3D models. At Stem Pharm, we are applying these principles to design PEG-based hydrogels for the development of in vitro ...
The use of physiologically relevant in vitro models plays an important role in driving down attrition rates and boosting the efficiency and success of drug discovery programs. ...
“EB003 demonstrated efficacy across multiple in vitro and in vivo models. Moreover, we observed significantly reduced STEC colonization and alleviated symptoms in 100% of treated animals in a disease model representative of the intended patient population. ...
HemoShear Therapeutics, Inc., a clinical stage company developing treatments for rare metabolic disorders, today announced the publication of in vitro pharmacology data in the journal Molecular Genetics and Metabolism, demonstrating that the oral small molecule HST5040 may be effective in treating Methylmalonic Acidemia (MMA) and Propionic Acidemia (PA). ...
The award will enable development of a novel in vitro model system of the enteric nervous system derived from alpha-synuclein overexpressing (ASO) mice to support the discovery of a small molecule for the treatment of Parkinson’s disease (PD). ...
Biofilm creation - among others - is one of the most important factors linked to infections and almost the only one that can be measured through simulation. T-Control demonstrated superiority vs gold standard, i.e. significant differences were observed between the biofilm quantity generated on the product´s surface. This result reinforces the hypothesis that T-Control, with it´s ...
Watkins' studies involve mouse genetic models, patients who have experienced or are experiencing DILI, and patient-specific liver culture models derived from stem cells. ...