MedChemExpress LLC (MCE)

MedChemExpress - Model Maprotiline - 10262-69-8

Maprotiline is a highly selective noradrenergic reuptake inhibitor that has strong antidepressant, antitumor and neuropathic pain-relieving effects. Maprotiline induces cancer cell apoptosis by targeting the ERK signaling pathway and CRABP1[1][2].

Maprotiline

MCE China：Maprotiline

Brand：MedChemExpress (MCE)

Cat. No.HY-B0444A

CAS：10262-69-8

Storage：Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping：Room temperature in continental US; may vary elsewhere.

Description：Maprotiline is a highly selective noradrenergic reuptake inhibitor that has strong antidepressant, antitumor and neuropathic pain-relieving effects. Maprotiline induces cancer cell apoptosis by targeting the ERK signaling pathway and CRABP1.

In Vitro：Maprotiline (0-20 μM, 0-72 h) inhibits the growth of Huh7 and HepG2 cells and induces cell apoptosis[1]. Maprotiline (0-20 μM, 0-72 h) inhibits the metastasis of liver cancer cells[1]. Maprotiline (0-20 μM, 72 h) affects the ERK pathway and inhibits the phosphorylation of SREBP2 in HepG2 and Huh7 cells[1]. Maprotiline targets CRABP1 and regulates cholesterol biosynthesis in HCC cells[1].

In Vivo：Maprotiline (20-40 mg/kg, intraperitoneal injection, twice a week for three weeks) inhibits liver cancer tumor growth in mice[1]. Maprotiline (3-30 mg/kg, intravenous injection, single dose) combined with the synthetic cannabinoid WIN 55,212-2 effectively reduces neuropathic pain in mice[2].

References：

[1]. Zheng C, et al. Maprotiline Suppresses Cholesterol Biosynthesis and Hepatocellular Carcinoma Progression Through Direct Targeting of CRABP1. Front Pharmacol. 2021 May 20. 12:689767. [Content Brief]

[2]. Gunduz O, et al. Analysis of the anti-allodynic effects of combination of a synthetic cannabinoid and a selective noradrenaline re-uptake inhibitor in nerve injury-induced neuropathic mice. Eur J Pain. 2016 Mar. 20(3):465-71.

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