MedChemExpress LLC (MCE)

MedChemExpress - Model Menthone - 10458-14-7

Menthone, an orally active monoterpene that can be isolated from plants and Mentha oil with antibacterial, antitumor, antioxidation, and antivirus properties. Menthone is a main volatile component of the essential oil, and has anti-Inflammatory properties in Schistosoma mansoni infection and rheumatoid arthritis[1][2].

Menthone

MCE China：Menthone

Brand：MedChemExpress (MCE)

Cat. No.HY-N2381

CAS：10458-14-7

Purity：98.0%

Storage：Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month

Shipping：Room temperature in continental US; may vary elsewhere.

Description：Menthone, an orally active monoterpene that can be isolated from plants and Mentha oil with antibacterial, antitumor, antioxidation, and antivirus properties. Menthone is a main volatile component of the essential oil, and has anti-Inflammatory properties in Schistosoma mansoni infection and rheumatoid arthritis.

In Vitro：Menthone (0.05-500 μM, 48 h) has optimal concentration for murine primary lung mast cells viability are 0.5, 5 and 50 μM[3]. Menthone (0.5-50 μM, 48 h) inhibits the secretion of proinflammatory cytokine TNF-α and have anti-inflammatory potential to LPS-stimulated lung mast cells[3]. Menthone (100 μM, 24 h) inhibits activation of the key transcription factor STAT1 of IFN-I signaling and promotes Tyk2 polyubiquitination to reduce Tyk2 protein levels in 2fTGH cells[4].

In Vivo：Menthone (100 mg/kg, Articulus injection, 14 days) inhibits the expression of Th1 and Th17 cells in CIA mouse model[1]. Menthone (8-200 mg/kg, i.g. , daily, 5 weeks) improves the allergic inflammatory statu of the lungs and airways in OVA-sensitized and challenged allergic asthmatic inflammation mouse model by modulating the Th2-biased immune balance and mitigating mast cell degranulation[3]. Menthone (100 mg/kg, Articulus injection, 14 days) contributes to the relief of local inflammation of rheumatoid arthritis in CIA mice[1][4].

IC50 & Target：Schistosome

References：

[1]. Chen X, et al. A Natural Plant Ingredient, Menthone, Regulates T Cell Subtypes and Lowers Pro-inflammatory Cytokines of Rheumatoid Arthritis. J Nat Prod. 2022 Apr 22;85(4):1109-1117. [Content Brief]

[2]. Mauricio G Zaia, et al. Anti-Inflammatory Properties of Menthol and Menthone in Schistosoma mansoni Infection. Front Pharmacol. 2016 Jun 17;7:170. [Content Brief]

[3]. Su YH, et al. Menthone supplementation protects from allergic inflammation in the lungs of asthmatic mice. Eur J Pharmacol. 2022 Sep 15;931:175222. [Content Brief]

[4]. Chen X, et al. Menthone inhibits type-I interferon signaling by promoting Tyk2 ubiquitination to relieve local inflammation of rheumatoid arthritis. Int Immunopharmacol. 2022 Nov;112:109228. [Content Brief]

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