MedChemExpress LLC (MCE)

MedChemExpress - Model Umifenovir hydrochloride - 131707-23-8

Umifenovir hydrochloride is a potent, orally active broad-spectrum antiviral with activity against a number of enveloped and non-enveloped viruses. Umifenovir hydrochloride is used as an anti-influenza virus agent. Umifenovir hydrochloride could effectively inhibit the fusion of virus with host cells[1][2]. Umifenovir hydrochloride is an efficient inhibitor of SARS-CoV-2 in vitro. Anti-inflammatory activity[3].

Umifenovir hydrochloride

MCE China：Umifenovir hydrochloride

Brand：MedChemExpress (MCE)

Cat. No.HY-14904A

CAS：131707-23-8

Purity：99.86%

Storage：4°C, sealed storage, away from moisture *In solvent : -80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture)

Shipping：Room temperature in continental US; may vary elsewhere.

Description：Umifenovir hydrochloride is a potent, orally active broad-spectrum antiviral with activity against a number of enveloped and non-enveloped viruses. Umifenovir hydrochloride is used as an anti-influenza virus agent. Umifenovir hydrochloride could effectively inhibit the fusion of virus with host cells. Umifenovir hydrochloride is an efficient inhibitor of SARS-CoV-2 in vitro. Anti-inflammatory activity.

In Vitro：Umifenovir hydrochloride exhibits a wide range and potent antiviral activity against a number of viruses including influenza A, B and C viruses, respiratory syncytial virus, adenovirus, parainfluenza type 5 and rhinovirus type 14, avian coronavirus, infectious bronchitis virus and Marek disease virus, hepatitis B virus and hepatitis C virus[1].

In Vivo：Umifenovir (45-180 mg/kg; p.o.; daily for 5 days) suppresses the transcription of influenza viruses (IFV) -associated inflammatory cytokines[2].

IC50 & Target：Antiviral; Anti-influenza agent Cellular Effect Cell Line Type Value Description References

References：

[1]. Boriskin YS, et al. Arbidol: a broad-spectrum antiviral compound that blocks viral fusion. Curr Med Chem. 2008;15(10):997-1005. [Content Brief]

[2]. Liu Q, et al. Antiviral and anti-inflammatory activity of arbidol hydrochloride in influenza A (H1N1) virus infection. Acta Pharmacol Sin. 2013;34(8):1075-1083. [Content Brief]

[3]. Wang X, et al. The anti-influenza virus drug, arbidol is an efficient inhibitor of SARS-CoV-2 in vitro. Cell Discov. 2020;6:28. Published 2020 May 2. [Content Brief]

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