MedChemExpress LLC (MCE)

MedChemExpress - Model Eriocitrin - 13463-28-0

Eriocitrin is a flavonoid isolated from lemons that is a powerful antioxidant. Eriocitrin inhibits the proliferation of liver cancer cells by arresting the cell cycle in the S phase by upregulating p53, cyclin A, cyclin D3 and CDK6. Eriocitrin triggers apoptosis by activating intrinsic signaling pathways involving mitochondria[1][1][2].

Eriocitrin

MCE China：Eriocitrin

Brand：MedChemExpress (MCE)

Cat. No.HY-N0636

CAS：13463-28-0

Purity：99.84%

Storage：4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Shipping：Room temperature in continental US; may vary elsewhere.

Description：Eriocitrin is a flavonoid isolated from lemons that is a powerful antioxidant. Eriocitrin inhibits the proliferation of liver cancer cells by arresting the cell cycle in the S phase by upregulating p53, cyclin A, cyclin D3 and CDK6. Eriocitrin triggers apoptosis by activating intrinsic signaling pathways involving mitochondria.

In Vitro：Eriocitrin (25-75 μM; 24 h) arrests the cell cycle in the S phase, (5-10 μM; 24 h) and inhibits proliferation and focus formation of liver cancer cell lines HepG2 and Huh7[1].Eriocitrin (25-75 μM; 12 h) upregulates p53, cyclin A, cyclin D3, and CDK6 levels in HepG2 cells[1].Eriocitrin (25-75 μM; 48 h) triggers apoptosis by activating mitochondria-related intrinsic signaling pathways[1].

In Vivo：Eriocitrin (10-60 mg/kg; ip; once daily, from the day of modeling until the end of the experiment) attenuates acute kidney injury (AKI) induced by ischemia reperfusion (IR) in rats, and reduces renal tissue cell apoptosis, turns its kidney inflammatory response and oxidative stress[2].

References：

[1]. Wang Z, et al. Eriocitrin from lemon suppresses the proliferation of human hepatocellular carcinoma cells through inducing apoptosis and arresting cell cycle. Cancer Chemother Pharmacol. 2016 Dec;78(6):1143-1150. [Content Brief]

[2]. Xu J, et al. Eriocitrin attenuates ischemia reperfusion-induced oxidative stress and inflammation in rats with acute kidney injury by regulating the dual-specificity phosphatase 14 (DUSP14)-mediated Nrf2 and nuclear factor-κB (NF-κB) pathways. Ann Transl Med. 2021 Feb;9(4):350. [Content Brief]

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