MedChemExpress - Model BMS-963272 - 1441057-15-3
BMS-963272 is an orally active and selective MGAT2 inhibitor (IC50 = 7.1 nM), used for the study of metabolic disorders and inflammatory diseases[1][2].MCE products for research use only. We do not sell to patients.
BMS-963272
MCE China：BMS-963272
Brand：MedChemExpress (MCE)
Cat. No.HY-132924
CAS：1441057-15-3
Purity：99.92%
Storage：Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping：Room temperature in continental US; may vary elsewhere.
Description：BMS-963272 is an orally active and selective MGAT2 inhibitor (IC50 = 7.1 nM), used for the study of metabolic disorders and inflammatory diseases.
In Vitro：BMS-963272 (10 min) has good metabolic properties, with 100% metabolic stability in both human and mouse liver microsomes[1].
In Vivo：BMS-963272 (30 mg/kg, p.o., twice daily, for 24 days) reduced body weight gain and significantly decreased food intake in the diet-induced obese mouse model[1]. BMS-963272 (0.3 and 3.0 mg/kg, p.o., once daily, for 8 weeks) exhibited potent antifibrotic and anti-inflammatory effects in the choline-deficient, amino acid-defined high-fat diet (CDAHFD)-induced non-alcoholic steatohepatitis (NASH) mouse model by reducing liver fibrosis and lowering the expression of inflammatory markers such as tumor necrosis factor-alpha (TNFa), further improving liver function as evidenced by decreased alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels[2].
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References：
[1]. Turdi H, et al. Screening Hit to Clinical Candidate: Discovery of BMS-963272, a Potent, Selective MGAT2 Inhibitor for the Treatment of Metabolic Disorders. J Med Chem. 2021 Oct 14;64(19):14773-14792. [Content Brief]
[2]. Cheng D, et al. MGAT2 inhibitor decreases liver fibrosis and inflammation in murine NASH models and reduces body weight in human adults with obesity. Cell Metab. 2022 Nov 1;34(11):1732-1748.e5. [Content Brief]
Brand introduction:
• MCE (MedChemExpress) has a global exclusive compound library of more than 200 kinds, and we are committed to providing the most comprehensive range of high-quality small molecule active compounds for scientific research customers around the world；
• More than 50,000 highly selective inhibitors and agonists are involved in various popular signaling pathways and disease areas；
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• The biological activity of the products has been verified by the experiments of customers in various countries；
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