MedChemExpress LLC (MCE)

MedChemExpress - Model Acenocoumarol - 152-72-7

FromMedChemExpress LLC (MCE)

Acenocoumarol is an anticoagulant that functions as a Vitamin K antagonist.

Acenocoumarol

MCE China：Acenocoumarol

Brand：MedChemExpress (MCE)

Cat. No.HY-B1014

CAS：152-72-7

Purity：99.87%

Storage：Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month

Shipping：Room temperature in continental US; may vary elsewhere.

Description：Acenocoumarol is an anticoagulant that functions as a Vitamin K antagonist. Acenocoumarol inhibits MAPK/ERK/JNK signaling pathway, reduces the nuclear translocation of NF-κB p65, activates Akt/GSK3β signaling pathway. Acenocoumarol induces apoptosis in cell A549, arrests cell cycle at S phase.

In Vitro：Acenocoumarol (30-500 μM, 24 h) inhibits the expression of iNOS and COX-2, inhibits the expression of NO, prostaglandin E2, TNF-α, IL-6 and IL-1β in LPS (HY-D1056)-stimulated RAW 264.7 cell[1]. Acenocoumarol (10-60 μM, 72 h) reduces the expression of tyrosinase, tyrosinase-related protein (TRP)-1, TRP-2 in αMSH-stimulated B16F10 melanoma cell, blocks melanin synthesis through PKA/JNK inhibition and Akt/GSK3β activation[2]. Acenocoumarol (0-100 μM, 24 h) exhibits cytotoxicity in cancer cell A549 and IMR-90 with IC50 of 28.75 μM and 74.11 μM[4].

In Vivo：Acenocoumarol (50-150 µg/kg, po, once daily for 14 days) alleviates ischemia/reperfusion-induced acute pancreatitis in Wistar rats models[3]. Acenocoumarol (0.2 mg/kg, po, once daily for 21 days) inhibits tumor growth, reduces cellular infiltration and inflammation in tumor tissues in A549-Xenograft mouse models[4].

References：

[1]. Han HJ, et al., Acenocoumarol Exerts Anti-Inflammatory Activity via the Suppression of NF-κB and MAPK Pathways in RAW 264.7 Cells. Molecules. 2023 Feb 22;28(5):2075. [Content Brief]

[2]. Han H, et al., Acenocoumarol, an Anticoagulant Drug, Prevents Melanogenesis in B16F10 Melanoma Cells. Pharmaceuticals (Basel). 2023 Apr 17;16(4):604. [Content Brief]

[3]. Warzecha Z, et al., Therapeutic Effect of Low Doses of Acenocoumarol in the Course of Ischemia/Reperfusion-Induced Acute Pancreatitis in Rats. Int. J. Mol. Sci.2017, 18, 882. Int J Mol Sci. 2019 Jun 24;20(12):3086. [Content Brief]

[4]. Maity S, et al. Exploring acenocoumarol and silodosin as allosteric EGFR inhibitors for the treatment of non-small cell lung cancer[J]. F1000Research, 2024, 13(1398): 1398.

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