MedChemExpress LLC (MCE)

MedChemExpress - Model Scytonemin - 152075-98-4

Scytonemin is a hydrophobic alkaloid pigment that can be isolated from the outer sheath of cyanobacteria. Scytonemin has protective function against short-wave solar ultraviolet (UV) radiation, which can reduce the generation of reactive oxygen species (ROS) and the formation of DNA damage. Scytonemin also has anti-inflammatory and anti-proliferative activities, produces concentration-dependent inhibition (IC50=2.0 μM) of polo-like kinase 1 (PLK1)-mediated cdc25C phosphorylation, and plays an important role in regulating the G2/M transition in the cell cycle. It can be used in the research of cancer, acute inflammation and sunscreen cosmetics[1][2][3][4][5].

Scytonemin

MCE China：Scytonemin

Brand：MedChemExpress (MCE)

Cat. No.HY-112356

CAS：152075-98-4

Purity：99.53%

Storage：Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month

Shipping：Room temperature in continental US; may vary elsewhere.

Description：Scytonemin is a hydrophobic alkaloid pigment that can be isolated from the outer sheath of cyanobacteria. Scytonemin has protective function against short-wave solar ultraviolet (UV) radiation, which can reduce the generation of reactive oxygen species (ROS) and the formation of DNA damage. Scytonemin also has anti-inflammatory and anti-proliferative activities, produces concentration-dependent inhibition (IC50=2.0 μM) of polo-like kinase 1 (PLK1)-mediated cdc25C phosphorylation, and plays an important role in regulating the G2/M transition in the cell cycle. It can be used in the research of cancer, acute inflammation and sunscreen cosmetics.

In Vitro：Scytonemin (3 μM; 24 h) inhibits the proliferation of human T-cell leukemia Jurkat cells (IC50= 7.8 μM) and induces apoptosis[4]. Scytonemin (100 nM-30 μM) has an inhibitory effect on PDGF-induced RSF and ECGF-induced HUVEC proliferation (IC50=1.5 μM; IC50=5.4 μM) [4].

In Vivo：Scytonemin has a highly effective inhibitory effect (ED50=10 mg/kg) on Phorbol 12-myristate 13-acetate (HY-18739) induced ear inflammation in mice when administered parenterally[3].

References：

[1]. Proteau PJ, et al. The structure of scytonemin, an ultraviolet sunscreen pigment from the sheaths of cyanobacteria. Experientia. 1993 Sep 15;49(9):825-9. [Content Brief]

[2]. Rastogi RP, et al. Cyanobacterial Sunscreen Scytonemin: Role in Photoprotection and Biomedical Research. Appl Biochem Biotechnol. 2015 Jul;176(6):1551-63. [Content Brief]

[3]. Gerwick, et al. "Antimutagenic, antiinflammatory, and potential anticancer substances from marine algae." Food Factors for Cancer Prevention. Springer Japan, 1997.

[4]. Stevenson, et al. "The identification and characterization of the marine natural product scytonemin as a novel antiproliferative pharmacophore." Journal of Pharmacology and Experimental Therapeutics 303.2 (2002): 858-866. [Content Brief]

[5]. Degenhardt, et al. "Targeting Polo-like kinase in cancer therapy." Clinical cancer research 16.2 (2010): 384-389. [Content Brief]

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