MedChemExpress - Model Compound C108 - 15533-09-2

Compound C108 is a G3BP2 inhibitor. Compound C108 also targeted stress granule-associated proteins and Gtpase-activating protein (SH3 domain) binding protein 2. Compound C108 potently inhibits esophageal squamous cell carcinoma (ESCC) cell metastasis[1][2].

Compound C108

MCE China：Compound C108

Brand：MedChemExpress (MCE)

Cat. No.HY-131649

CAS：15533-09-2

Purity：98.66%

Storage：4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Shipping：Room temperature in continental US; may vary elsewhere.

Description：Compound C108 is a G3BP2 inhibitor. Compound C108 also targeted stress granule-associated proteins and Gtpase-activating protein (SH3 domain) binding protein 2. Compound C108 potently inhibits esophageal squamous cell carcinoma (ESCC) cell metastasis.

In Vitro：Compound C108 (1 μM; 24 h) shows anti-tumor activity against BT474 cells[1]. Compound C108 (4 μM; 24 h) significantly decreases the protein expression of G3BP2 in G3BP2 overexpressing KYSE410 cells and LINC01554 transfected KYSE30 cells[2]. Compound C108 (4 μM; 24 h) attenuates ESCC cell metastasis, migration and invasion in KYSE410, KYSE30 and KYSE150 cells[2].

In Vivo：Compound C108 (1 μM; 24 h) targets and decreases tumor initiating cells (TICs), while injected BT-474 cells treated with Compound C108 into the mammary fat pad of female nonobese diabetic/severe combined immune deficiency (NOD-SCID) mice in a limiting-dilution xenograft assay[1].

IC50 & Target：G3BP2[1] In Vitro Compound C108 (1 μM; 24 h) shows anti-tumor activity against BT474 cells[1]. Compound C108 (4 μM; 24 h) significantly decreases the protein expression of G3BP2 in G3BP2 overexpressing KYSE410 cells and LINC01554 transfected KYSE30 cells[2]. Compound C108 (4 μM; 24 h) attenuates ESCC cell metastasis, migration and invasion in KYSE410, KYSE30 and KYSE150 cells[2]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Compound C108 Related Antibodies Western Blot Analysis[2] Cell Line: G3BP2-overexpressing KYSE410 cells, LINC01554-transfected KYSE30 cells

References：

[1]. Gupta N, et al. Stress granule-associated protein G3BP2 regulates breast tumor initiation. Proc Natl Acad Sci U S A. 2017 Jan 31;114(5):1033-1038. [Content Brief]

[2]. Zheng Y, et al. G3BP2 regulated by the lncRNA LINC01554 facilitates esophageal squamous cell carcinoma metastasis through stabilizing HDGF transcript. Oncogene. 2022 Jan;41(4):515-526. [Content Brief]

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