MedChemExpress LLC (MCE)

MedChemExpress - Model Hinokiflavone - 19202-36-9

Hinokiflavone is a novel modulator of pre-mRNA splicing activity extracted from plants with anti-inflammatory, anti-tumor and antiviral activities. Hinokiflavone is also a potent inhibitor for matrix metalloproteinases (MMPs). Hinokiflavone attenuates the virulence of Methicillin (HY-121544)-resistant staphylococcus aureus by inhibiting caseinolytic protease P (ClpP) with an IC50 value of 34.36 mg/mL. Hinokiflavone induces apoptosis via the reactive oxygen species-mitochondria-mediated apoptotic pathway and inhibits tumor cell migration and invasion. Hinokiflavone is a SUMO protease inhibitor against sentrin-specific protease 1 (SENP1) activity[1][2][3].

Hinokiflavone

MCE China：Hinokiflavone

Brand：MedChemExpress (MCE)

Cat. No.HY-N2360

CAS：19202-36-9

Purity：99.80%

Storage：4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Shipping：Room temperature in continental US; may vary elsewhere.

Description：Hinokiflavone is a novel modulator of pre-mRNA splicing activity extracted from plants with anti-inflammatory, anti-tumor and antiviral activities. Hinokiflavone is also a potent inhibitor for matrix metalloproteinases (MMPs). Hinokiflavone attenuates the virulence of Methicillin (HY-121544)-resistant staphylococcus aureus by inhibiting caseinolytic protease P (ClpP) with an IC50 value of 34.36 mg/mL. Hinokiflavone induces apoptosis via the reactive oxygen species-mitochondria-mediated apoptotic pathway and inhibits tumor cell migration and invasion. Hinokiflavone is a SUMO protease inhibitor against sentrin-specific protease 1 (SENP1) activity.

In Vitro：Hinokiflavone (500 μM, 90 min) inhibits splicing of the adenovirus and the HPV18E6 pre-mRNAs, showed a stronger effect on pre-mRNA splicing than Isoginkgetin (HY-N2117) in vitro[1]. Hinokiflavone (0-30 μM, 24 h) induces either cell cycle arrest or eventual cell death and increases levels of SUMOylated proteins by inhibiting sentrin-specific protease 1 (SENP1) activity in HEK 293 cells[1]. Hinokiflavone (0-40 μM, 24 h) suppresses colorectal tumor cell proliferation, cell migration and invasion ability but promotes cell Apoptosis via the mitochondria-mediated apoptotic pathway[2]. Hinokiflavone (0-128 μg/mL, 24 h) reduces the expression of virulence factors in staphylococcus aureus by directly interacting with caseinolytic protease P (ClpP)[3].

In Vivo：Hinokiflavone (25 or 50 mg/kg, i.p., daily for 24 days) has antitumor activity via suppressing tumor proliferation, metastasis and inducing Apoptosis in CT26 tumor-bearing mice[2]. Hinokiflavone (100 mg/kg, s.c., every 12 h for 96 h) shows a protective effect on pneumonia infection by Improving survival rate in mice[3].

References：

[1]. Pawellek A, et al. Characterisation of the biflavonoid hinokiflavone as a pre-mRNA splicing modulator that inhibits SENP. Elife. 2017 Sep 8;6. pii: e27402. [Content Brief]

[2]. Zhou J, et al. Antitumor activity in colorectal cancer induced by hinokiflavone. J Gastroenterol Hepatol. 2019 Sep;34(9):1571-1580. [Content Brief]

[3]. Kong X, et al. Hinokiflavone Attenuates the Virulence of Methicillin-Resistant Staphylococcus aureus by Targeting Caseinolytic Protease P. Antimicrob Agents Chemother. 2022 Aug 16;66(8):e0024022. [Content Brief]

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