MedChemExpress LLC (MCE)

MedChemExpress - Model Chlorin e6 - 19660-77-6

Chlorin e6 is a photosensitizer and has strong absorption peaks at wavelength of 402 and 662 nm, as well as exhibiting intense fluorescence at 668 nm. Chlorin e6 has antimicrobial efficacy and anticancer activity. Chlorin e6 induces cell apoptosis via caspase-3 activation and can be used for the research of cancer[1][2][3].

Chlorin e6

MCE China：Chlorin e6

Brand：MedChemExpress (MCE)

Cat. No.HY-13594

CAS：19660-77-6

Synonyms：Ce6

Purity：98.38%

Storage：-20°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Shipping：Room temperature in continental US; may vary elsewhere.

Description：Chlorin e6 is a photosensitizer and has strong absorption peaks at wavelength of 402 and 662 nm, as well as exhibiting intense fluorescence at 668 nm. Chlorin e6 has antimicrobial efficacy and anticancer activity. Chlorin e6 induces cell apoptosis via caspase-3 activation and can be used for the research of cancer.

In Vitro：Chlorin e6 (100 μg/mL, 24 h) with laser light (635 nm) exhibits no toxicity viability in HT-29 cells[2]. Chlorin e6 (5-10 μM, 3 h) with near-infrared laser light (660 nm) induces pancreatic cancer cell apoptosis via caspase-3 activation, resulting in tumor growth suppression in AsPC-1 and MIA PaCa-2 cells[3].

In Vivo：Chlorin e6 (2.5 mg/kg, Intravenous injection, single dose) with a red light at a rate of 100 J/cm2 for 8 min 20 s has anti-tumor activity in B16F10 melanoma cells and PANC02 Pancreatic Cells xenograft mouse model[3]. Chlorin e6 (2.5 mg/kg, Intravenous injection, single dose) with near-infrared laser light (660 nm) suppresses the tumor growth in canine tumors[3].

IC50 & Target：Leishmania Bax Bcl-2 Caspase 3 PARP-1

References：

[1]. Nie M, et al. Photodynamic inactivation mediated by methylene blue or chlorin e6 against Streptococcus mutans biofilm [J]. Photodiagnosis and photodynamic therapy, 2020, 31: 101817. [Content Brief]

[2]. Karuppusamy S, et al. Nanoengineered chlorin e6 conjugated with hydrogel for photodynamic therapy on cancer [J]. Colloids and Surfaces B: Biointerfaces, 2019, 181: 778-788. [Content Brief]

[3]. Shrestha R, et al. Effect of Photodynamic Therapy with Chlorin e6 on Canine Tumors [J]. Life, 2022, 12(12): 2102. [Content Brief]

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