MedChemExpress LLC (MCE)

MedChemExpress - Model Calcium dobesilate - 20123-80-2

Calcium dobesilate is a vascular protector with oral activity that can clear hydroxyl free radicals, with an IC50 of 1.1 pM. Calcium dobesilate has antioxidant activity and helps to reduce oxidative stress and inflammation in the retinas of diabetic mice. Calcium dobesilate can be used to study chronic venous diseases, diabetic retinopathy, and the occurrence of hemorrhoids, among other conditions[1][2][3].

Calcium dobesilate

MCE China：Calcium dobesilate

Brand：MedChemExpress (MCE)

Cat. No.HY-111603

CAS：20123-80-2

Purity：99.82%

Storage：4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Shipping：Room temperature in continental US; may vary elsewhere.

Description：Calcium dobesilate is a vascular protector with oral activity that can clear hydroxyl free radicals, with an IC50 of 1.1 pM. Calcium dobesilate has antioxidant activity and helps to reduce oxidative stress and inflammation in the retinas of diabetic mice. Calcium dobesilate can be used to study chronic venous diseases, diabetic retinopathy, and the occurrence of hemorrhoids, among other conditions.

In Vitro：Calcium dobesilate (500 μM) significantly reduces the chemiluminescence of human PMN cells induced by platelet-activating factor (PAF) and decreases lipid peroxidation caused by oxygen free radicals in human red blood cell membranes[1]. Calcium dobesilate (5-10 mM) lowers MDA levels in human red blood cells[1]. Calcium dobesilate (0-10000 μM, for 5 days) at higher concentrations leads to a rapid decrease in live cells and an increase in the percentage of apoptotic cells[2].

In Vivo：Calcium dobesilate (200 mg/kg, once daily, for 15 days) exhibits antioxidant and anti-inflammatory activities and reduces biomarkers of oxidative stress in the retina of db/db mice[3].

References：

[1]. J Brunet, et al. In vitro antioxidant properties of calcium dobesilate. Fundam Clin Pharmacol. 1998;12(2):205-12. [Content Brief]

[2]. GA Losa, et al. Prevention of Oxidation and Apoptosis in Human Peripheral Blood Mononuclear Cells Exposed to Calcium Dobesilate. Int J Angiol. 1999;8(5):11-15. [Content Brief]

[3]. Patricia Bogdanov, et al. Calcium dobesilate prevents the oxidative stress and inflammation induced by diabetes in the retina of db/db mice. J Diabetes Complications. 2017 Oct;31(10):1481-1490. [Content Brief]

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