MedChemExpress - Model Calycosin - 20575-57-9

Calycosin is a compound that can be isolated from Radix Astragali. Calycosin has strong antioxidant, anti-inflammatory and apoptosis-modulating effects. Calycosin can be used for the research of ovarian cancer and breast cancer[1][2].

Calycosin

MCE China：Calycosin

Brand：MedChemExpress (MCE)

Cat. No.HY-N0519

CAS：20575-57-9

Synonyms：Cyclosin

Purity：99.96%

Storage：Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year

Shipping：Room temperature in continental US; may vary elsewhere.

Description：Calycosin is a compound that can be isolated from Radix Astragali. Calycosin has strong antioxidant, anti-inflammatory and apoptosis-modulating effects. Calycosin can be used for the research of ovarian cancer and breast cancer.

In Vitro：Calycosin (0-100 μM, 24-72 h) inhibits the proliferation of SKOV3 cells in a dose- and time-dependent manner[1]. Calycosin (25-100 μM, 48 h) upregulates the Bax/Bcl-2 ratio and the expression of cleaved caspase-3 and cleaved caspase-9 in a dose-dependent manner in SKOV3 cells[1]. Calycosin (0-16 μM, 0-240 min) stimulates rapid activation of ERK1/2 in a time- and dose-dependent manner in MCF-7 cells[2].

In Vivo：Calycosin (1-4 mg/kg, i.p., daily, 20 days) inhibits the protein expression of ERα in OVX mice at the doses of 1 mg/kg[2]. Calycosin (7.5-30 mg/kg, i.g., daily, 3 days) has a neuroprotective effect against cerebral ischemia/reperfusion injury in adult male Sprague-Dawley rats[3].

References：

[1]. Zhou Y, et al. Calycosin induces apoptosis in human ovarian cancer SKOV3 cells by activating caspases and Bcl-2 family proteins. Tumour Biol. 2015 Feb 12. [Content Brief]

[2]. Chen J, et al. Calycosin promotes proliferation of estrogen receptor-positive cells via estrogen receptors and ERK1/2 activation in vitro and in vivo. Cancer Lett. 2011 Sep 28;308(2):144-51. [Content Brief]

[3]. Guo C, et al. Neuroprotective effect of calycosin on cerebral ischemia and reperfusion injury in rats. J Ethnopharmacol. 2012 Dec 18;144(3):768-74. [Content Brief]

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