MedChemExpress LLC (MCE)

MedChemExpress - Model Butin - 21913-99-5

Butin is a major biologically active flavonoid isolated from the heartwood of Dalbergia odorifera with oral activity, with strong antioxidant, antiplatelet and anti-inflammatory activities. Butin significantly alleviates myocardial infarction and improves heart function, together with prevents diabetes-induced cardiac oxidative damage in rat[1][2].

Butin

MCE China：Butin

Brand：MedChemExpress (MCE)

Cat. No.HY-N6020B

CAS：21913-99-5

Purity：99.34%

Storage：Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month

Shipping：Room temperature in continental US; may vary elsewhere.

Description：Butin is a major biologically active flavonoid isolated from the heartwood of Dalbergia odorifera with oral activity, with strong antioxidant, antiplatelet and anti-inflammatory activities. Butin significantly alleviates myocardial infarction and improves heart function, together with prevents diabetes-induced cardiac oxidative damage in rat.

In Vitro：Butin (12.5-50 μM, 6 h) reduces cell apoptosis and death caused by I/R injury in H9c2 cells, and this effect is dose-dependent[1]. Butin (12.5-50 μM, 6 h) disrupts the interaction between Nrf2 and Keap1 in a dose-dependent manner[1]. Butin (12.5-50 μM, 6 h) increases the expression of antioxidant genes at both the mRNA and protein levels[1].

In Vivo：Butin (10-40 mg/kg, orally, twice a day, 15 days) can significantly reduce myocardial ischemia-reperfusion injury in diabetic mice, improve heart function, and increase the ability to resist oxidative stress[1]. Butin (25-50 mg/kg, intraperitoneal injection, single dose) can reduce behavioral changes and neuronal conditions in rats with cerebral hemorrhage by reducing apoptosis and inflammatory responses[2].

References：

[1]. Duan J, et al. Protective effect of butin against ischemia/reperfusion-induced myocardial injury in diabetic mice: involvement of the AMPK/GSK-3β/Nrf2 signaling pathway. Sci Rep. 2017 Jan 27;7:41491. [Content Brief]

[2]. Li P, et al. Butin Attenuates Brain Edema in a Rat Model of Intracerebral Hemorrhage by Anti Inflammatory Pathway. Transl Neurosci. 2018 May 8;9:7-12. [Content Brief]

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