MedChemExpress - Model Benfotiamine - 22457-89-2
Benfotiamine (S-Benzoylthiamine O-monophosphate) is a vitamin B1 derivative that exhihibits potent antioxidative and anti-inflammatory activity. Benfotiamine can be used for the research of various secondary diabetic complications. Benfotiamine also can be used in infectious diseases such as HIV and COVID-19[1][2][3].MCE products for research use only. We do not sell to patients.
Benfotiamine
MCE China：Benfotiamine
Brand：MedChemExpress (MCE)
Cat. No.HY-17374
CAS：22457-89-2
Synonyms：S-Benzoylthiamine O-monophosphate
Purity：99.39%
Storage：Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Shipping：Room temperature in continental US; may vary elsewhere.
Description：Benfotiamine (S-Benzoylthiamine O-monophosphate) is a vitamin B1 derivative that exhihibits potent antioxidative and anti-inflammatory activity. Benfotiamine can be used for the research of various secondary diabetic complications. Benfotiamine also can be used in infectious diseases such as HIV and COVID-19.
In Vitro：Benfotiamine (50-250 μM; pretreated for 30 min and then exposed to LPS for 24 h) decreases LPS-induced production of NO by suppressing iNOS-mRNA and protein level in BV-2 cells[2]. Benfotiamine (50-250 μM; pretreated for 30 min and then exposed to LPS for 6 h) suppresses LPS-induced PTGS mRNA expression and COX-2 protein expression in BV2 microglial cells[2].
In Vivo：Benfotiamine (100 mg/kg; i.p. for 14 d) alleviates STZ (HY-13753)-induced cerebral oxidative damage of FVB mice[3].
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References：
[1]. Allowitz KV, et, al. Therapeutic potential of vitamin B1 derivative benfotiamine from diabetes to COVID-19. Future Med Chem. 2022 Jun;14(11):809-826. [Content Brief]
[2]. Bozic I, et, al. Benfotiamine attenuates inflammatory response in LPS stimulated BV-2 microglia. PLoS One. 2015 Feb 19;10(2):e0118372. [Content Brief]
[3]. Wu S, et, al. Benfotiamine alleviates diabetes-induced cerebral oxidative damage independent of advanced glycation end-product, tissue factor and TNF-alpha. Neurosci Lett. 2006 Feb 13;394(2):158-62. [Content Brief]
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